Circuit-level theories for sensory dysfunction in autism: convergence across mouse models

HR Monday, HC Wang, DE Feldman - Frontiers in Neurology, 2023 - frontiersin.org
Individuals with autism spectrum disorder (ASD) exhibit a diverse range of behavioral
features and genetic backgrounds, but whether different genetic forms of autism involve …

Application of medial ganglionic eminence cell transplantation in diseases associated with interneuron disorders

D Li, Q Wu, X Han - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Excitatory projection neurons and inhibitory interneurons primarily accomplish the neural
activity of the cerebral cortex, and an imbalance of excitatory-inhibitory neural networks may …

Symmetry in frontal but not motor and somatosensory cortical projections

AE Papale, M Harish, RF Paletzki… - Journal of …, 2024 - jneurosci.org
The neocortex and striatum are topographically organized for sensory and motor functions.
While sensory and motor areas are lateralized for touch and motor control, respectively …

Deletions of Cacna2d3 in parvalbumin-expressing neurons leads to autistic-like phenotypes in mice

W Shao, H Zheng, J Zhu, W Li, Y Li, W Hu… - Neurochemistry …, 2023 - Elsevier
Autism spectrum disorder (ASD) is a series of highly inherited neurodevelopmental
disorders. Loss-of-function (LOF) mutations in the CACNA2D3 gene are associated with …

[HTML][HTML] Timed fetal inflammation and postnatal hypoxia cause cortical white matter injury, interneuron imbalances, and behavioral deficits in a double-hit rat model of …

MJV Brandt, CM Kosmeijer, EJM Achterberg… - Brain, Behavior, & …, 2024 - Elsevier
Extreme preterm birth-associated adversities are a major risk factor for aberrant brain
development, known as encephalopathy of prematurity (EoP), which can lead to long-term …

R-Baclofen Treatment Corrects Autistic-like Behavioral Deficits in the RjIbm (m): FH Fawn-Hooded Rat Strain

A Varga, R Kedves, K Sághy, D Garab… - …, 2024 - pmc.ncbi.nlm.nih.gov
The Fawn-hooded rat has long been used as a model for various peripheral and central
disorders and the data available indicate that the social behavior of this strain may be …

Lateralized changes in language associated auditory and somatosensory cortices in autism

T Deemyad - Frontiers in Systems Neuroscience, 2022 - frontiersin.org
Lateralized specialization of the two cerebral hemispheres is a fundamental structural
hallmark of the human brain and underlies many cognitive functions and behavioral abilities …

Tactile sensory processing deficits in genetic mouse models of autism spectrum disorder

M Falcão, P Monteiro, L Jacinto - Journal of Neurochemistry, 2024 - Wiley Online Library
Altered sensory processing is a common feature in autism spectrum disorder (ASD), as
recognized in the Diagnostic and Statistical Manual of Mental Disorders (DSM‐5). Although …

Fxr1 Deletion from Cortical Parvalbumin Interneurons Modifies Their Excitatory Synaptic Responses

KS Scheuer, AM Jansson, M Shen, X Zhao… - eneuro, 2025 - eneuro.org
Fragile X autosomal homolog 1 (FXR1), a member of the fragile X messenger riboprotein 1
family, has been linked to psychiatric disorders including autism and schizophrenia …

Degraded tactile coding in the Cntnap2 mouse model of autism

HC Wang, DE Feldman - Cell reports, 2024 - cell.com
Atypical sensory processing is common in autism, but how neural coding is disrupted in
sensory cortex is unclear. We evaluate whisker touch coding in L2/3 of somatosensory …