Transmitter signalling is the universal chemical language of any nervous system, but little is
known about its early evolution. Here, we summarize data about the distribution and …

Extracellular adenosine triphosphate (ATP) serves as a signal for diverse physiological
functions, including spread of calcium waves between astrocytes, control of vascular oxygen …

The Pannexin1 (Panx1) membrane channel responds to different stimuli with distinct
channel conformations. Most stimuli induce a large cation‐and ATP‐permeable …

An efficient harvest of hematopoietic stem/progenitor cells (HSPCs) after pharmacological
mobilization from the bone marrow (BM) into peripheral blood (PB) and subsequent proper …

Kidney function and blood pressure homeostasis are regulated by purinergic signaling
mechanisms. These autocrine/paracrine signaling pathways are initiated by the release of …

Abstract Pannexin‐1 (Panx1) forms plasma membrane channels that allow the exchange of
small molecules between the intracellular and extracellular compartments, and are involved …

To ensure appropriate secretion in response to demand,(neuro) endocrine tissues liberate
massive quantities of hormones, which act to coordinate and synchronize biological signals …

Over the last decades, since the discovery of ATP as a transmitter, accumulating evidence
has been reported about the role of this nucleotide and purinergic receptors, in particular …

Background and Purpose ATP is highly accumulated in secretory vesicles and secreted
upon exocytosis from neurons and endocrine cells. In adrenal chromaffin granules …

Cx43 hemichannels (HCs) and Panx1 channels are two genetically distant protein families.
Despite the lack of sequence homology, Cx43 and Panx1 channels have been the subject of …