Melatonin modulates a wide range of physiological functions with pleiotropic effects on the
immune system. Despite the large number of reports implicating melatonin as an …

The pineal hormone melatonin has attracted great scientific interest since its discovery in
1958. Despite the enormous number of basic and clinical studies the exact role of melatonin …

Many of melatonin's actions are mediated through interaction with the G-protein coupled
membrane bound melatonin receptors type 1 and type 2 (MT1 and MT2, respectively) or …

Melatonin is the major secretory product synthesized and secreted by the pineal gland and
shows both a wide distribution within phylogenetically distant organisms from bacteria to …

Seasonal changes in disease activity have been observed in multiple sclerosis, an
autoimmune disorder that affects the CNS. These epidemiological observations suggest that …

Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent
alterations in brain regions involved in emotional regulation have been suggested as an …

Melatonin affects a variety of physiological processes including circadian rhythms, cellular
redox status, and immune function. Importantly, melatonin significantly influences T‐cell …

This review summarizes the numerous observations published in recent years which have
shown that one of the most significant of melatonin's pleiotropic effects is the regulation of …

Melatonin is an evolutionarily conserved molecule that serves a time-keeping function in
various species. In vertebrates, melatonin is produced predominantly by the pineal gland …

It is commonly accepted that melatonin (N-acetyl-5-methoxytryptamine), the most relevant
pineal secretory product, has oncostatic properties in a wide variety of tumors and …