The next generation of evidence-based medicine

V Subbiah - Nature medicine, 2023 - nature.com
Recently, advances in wearable technologies, data science and machine learning have
begun to transform evidence-based medicine, offering a tantalizing glimpse into a future of …

Cytokine storm

DC Fajgenbaum, CH June - New England Journal of Medicine, 2020 - Mass Medical Soc
Cytokine Storm Cytokine storm, a life-threatening disorder involving cytokine elevations and
immune-cell hyperactivation, has various causes and is characterized by constitutional …

Overview of Castleman disease

A Dispenzieri, DC Fajgenbaum - Blood, The Journal of the …, 2020 - ashpublications.org
Castleman disease (CD) describes a group of at least 4 disorders that share a spectrum of
characteristic histopathological features but have a wide range of etiologies, presentations …

Therapeutic blockade of inflammation in severe COVID-19 infection with intravenous N-acetylcysteine

H Ibrahim, A Perl, D Smith, T Lewis, Z Kon… - Clinical …, 2020 - Elsevier
Abstract Glucose 6-phosphate dehydrogenase (G6PD) deficiency facilitates human
coronavirus infection due to glutathione depletion. G6PD deficiency may especially …

Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes

JT England, A Abdulla, CM Biggs, AYY Lee, KA Hay… - Blood Reviews, 2021 - Elsevier
A subset of patients with severe COVID-19 develop profound inflammation and multi-organ
dysfunction consistent with a “Cytokine Storm Syndrome”(CSS). In this review we compare …

Castleman disease

A Carbone, M Borok, B Damania, A Gloghini… - Nature Reviews …, 2021 - nature.com
Castleman disease (CD), a heterogeneous group of disorders that share morphological
features, is divided into unicentric CD and multicentric CD (MCD) according to the clinical …

Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate IL-6-induced acute liver injury through miR-455-3p

M Shao, Q Xu, Z Wu, Y Chen, Y Shu, X Cao… - Stem cell research & …, 2020 - Springer
Background Using a toxin-induced nonhuman primate model of acute liver failure (ALF), we
previously reported that peripheral infusion of human umbilical cord mesenchymal stem …

Is severe COVID-19 a cytokine storm syndrome: a hyperinflammatory debate

P Mehta, DC Fajgenbaum - Current opinion in Rheumatology, 2021 - journals.lww.com
Hyperinflammation is a key component of severe COVID-19, residing underneath the
cytokine storm umbrella term, associated with poor outcomes. Better understanding of the …

Peripheral helper-T-cell-derived CXCL13 is a crucial pathogenic factor in idiopathic multicentric Castleman disease

T Harada, Y Kikushige, T Miyamoto, K Uno… - Nature …, 2023 - nature.com
Castleman disease (CD) is a rare lymphoproliferative disorder. Among subtypes of CD,
idiopathic multicentric CD-not otherwise specified (iMCD-NOS) has a poor prognosis and its …

Diabetic ferroptosis plays an important role in triggering on inflammation in diabetic wound

S Li, Y Li, Z Wu, Z Wu, H Fang - American Journal of …, 2021 - journals.physiology.org
Impaired wound healing is a major complication of diabetes and involves sustained
inflammation and oxidative stress at the wound site. Here, we investigated the potential …