Growth factors, PI3K/AKT/mTOR and MAPK signaling pathways in colorectal cancer pathogenesis: where are we now?

C Stefani, D Miricescu, II Stanescu-Spinu… - International journal of …, 2021 - mdpi.com
Colorectal cancer (CRC) is a predominant malignancy worldwide, being the fourth most
common cause of mortality and morbidity. The CRC incidence in adolescents, young adults …

The fight against cancer by microgravity: the multicellular spheroid as a metastasis model

D Grimm, H Schulz, M Krüger… - International Journal of …, 2022 - mdpi.com
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …

Heterogeneous microenvironmental stiffness regulates pro-metastatic functions of breast cancer cells

C Liu, M Li, ZX Dong, D Jiang, X Li, S Lin, D Chen… - Acta biomaterialia, 2021 - Elsevier
Besides molecular and phenotypic variations observed in cancer cells, intratumoral
heterogeneity also occurs in the tumor microenvironment. Correlative stiffness maps of …

Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells

D Grimm, M Wehland, TJ Corydon… - Stem cells …, 2020 - academic.oup.com
A spaceflight has enormous influence on the health of space voyagers due to the combined
effects of microgravity and cosmic radiation. Known effects of microgravity (μ g) on cells are …

A 3D-printed biphasic calcium phosphate scaffold loaded with platelet lysate/gelatin methacrylate to promote vascularization

G Liu, B Zhang, T Wan, C Zhou, Y Fan… - Journal of Materials …, 2022 - pubs.rsc.org
3D-printed biphasic calcium phosphate (BCP) scaffolds show great clinical application
potential in bone tissue engineering; however, vascularization of the scaffold is a crucial …

VEGF/VEGFR axis and its signaling in melanoma: Current knowledge toward therapeutic targeting agents and future perspectives

M Malekan, NK Haass, GR Rokni, N Gholizadeh… - Life sciences, 2024 - Elsevier
Melanoma is responsible for most skin cancer-associated deaths globally. The progression
of melanoma is influenced by a number of pathogenic processes. Understanding the …

[HTML][HTML] The impact of spaceflight and simulated microgravity on cell adhesion

X Lin, K Zhang, D Wei, Y Tian, Y Gao, Z Chen… - International Journal of …, 2020 - mdpi.com
Microgravity induces a number of significant physiological changes in the cardiovascular,
nervous, immune systems, as well as the bone tissue of astronauts. Changes in cell …

Extraterrestrial gynecology: could spaceflight increase the risk of developing cancer in female astronauts? An updated review

R Drago-Ferrante, R Di Fiore, F Karouia… - International journal of …, 2022 - mdpi.com
Outer space is an extremely hostile environment for human life, with ionizing radiation from
galactic cosmic rays and microgravity posing the most significant hazards to the health of …

Simulated microgravity attenuates skin wound healing by inhibiting dermal fibroblast migration via F‐actin/YAP signaling pathway

Y Zhou, W Lv, X Peng, Y Cheng, Y Tu… - Journal of Cellular …, 2023 - Wiley Online Library
Skin and its cell components continuously subject to extrinsic and intrinsic mechanical
forces and are mechanical sensitive. Disturbed mechanical homeostasis may lead to …