Tumorigenesis mechanisms found in hereditary renal cell carcinoma: a review

BR Webster, N Gopal, MW Ball - Genes, 2022 - mdpi.com
Renal cell carcinoma is a heterogenous cancer composed of an increasing number of
unique subtypes each with their own cellular and tumor behavior. The study of hereditary …

Review of prognostic expression markers for clear cell renal cell carcinoma

F Petitprez, M Ayadi, AL De Reyniès… - Frontiers in …, 2021 - frontiersin.org
Context: The number of prognostic markers for clear cell renal cell carcinoma (ccRCC) has
been increasing regularly over the last 15 years, without being integrated and compared …

[HTML][HTML] Expression and mutation patterns of PBRM1, BAP1 and SETD2 mirror specific evolutionary subtypes in clear cell renal cell carcinoma

S Bihr, R Ohashi, AL Moore, JH Rüschoff, C Beisel… - Neoplasia, 2019 - Elsevier
Bi-allelic inactivation of the VHL gene on chromosome 3p is the characteristic feature in
most clear cell renal cell carcinomas (ccRCC). Frequent gene alterations were also …

BAP1-Mutated Clear Cell Renal Cell Carcinoma: A Clinicopathologic Characterization of 14 Molecularly Confirmed Tumors

AJ Gallan, M Parilla, J Segal… - American Journal of …, 2021 - academic.oup.com
Objectives While aberrations in the VHL gene and chromosome 3p resulting in clear cell
renal cell carcinoma (CCRCC) are well established, we know that additional mutations in …

[HTML][HTML] BAP1 is altered by copy number loss, mutation, and/or loss of protein expression in more than 70% of malignant peritoneal mesotheliomas

N Leblay, F Leprêtre, N Le Stang… - Journal of Thoracic …, 2017 - Elsevier
Introduction Malignant mesothelioma is a deadly disease that is strongly associated with
asbestos exposure. Peritoneal mesotheliomas account for 10% of all the cases. BRCA1 …

[HTML][HTML] Knockdown of long noncoding RNA FTX inhibits proliferation, migration, and invasion in renal cell carcinoma cells

X He, F Sun, F Guo, K Wang, Y Gao, Y Feng… - Oncology …, 2017 - ncbi.nlm.nih.gov
Renal cell carcinoma (RCC) is one of the most common kidney cancers worldwide. Although
great progressions have been made in the past decades, its morbidity and lethality remain …

Germline mutations of renal cancer predisposition genes and clinical relevance in Chinese patients with sporadic, early‐onset disease

J Wu, H Wang, CJ Ricketts, Y Yang, MJ Merino… - Cancer, 2019 - Wiley Online Library
Background An inherited susceptibility to renal cancers is associated with multiple
predisposing genes, but most screening tests are limited to patients with a family history …

Development and Validation of a CT-Based Radiomics Nomogram for Predicting Postoperative Progression-Free Survival in Stage I–III Renal Cell Carcinoma

H Zhang, F Yin, M Chen, L Yang, A Qi, W Cui… - Frontiers in …, 2022 - frontiersin.org
Background Many patients experience recurrence of renal cell carcinoma (RCC) after
radical and partial nephrectomy. Radiomics nomogram is a newly used noninvasive tool that …

Molecular and metabolic basis of clear cell carcinoma of the kidney

M Akhtar, IA Al-Bozom, T Al Hussain - Advances in anatomic …, 2018 - journals.lww.com
Renal cell carcinoma (RCC) is a heterogenous group of tumors,> 70% of which belong to
the category of clear cell carcinoma. In recent years, crucial advances have been made in …

Prognostic impact of concomitant loss of PBRM1 and BAP1 protein expression in early stages of clear cell renal cell carcinoma

WH da Costa, IW da Cunha, AF Fares… - … Oncology: Seminars and …, 2018 - Elsevier
Purpose To evaluate the prognostic impact of immunohistochemical expression of BAP1
and PBRM1 in patients with early stage (pT1–pT2N0M0) clear cell renal cell carcinoma …