[HTML][HTML] Lymphatic vessel network structure and physiology

JW Breslin, Y Yang, JP Scallan, RS Sweat… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

The pathogenesis of cardiac fibrosis: a review of recent progress

K Maruyama, K Imanaka-Yoshida - International journal of molecular …, 2022 - mdpi.com
Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) proteins in the
interstitium. It is an essential pathological response to chronic inflammation. ECM protein …

A human cell atlas of fetal gene expression

J Cao, DR O'day, HA Pliner, PD Kingsley, M Deng… - Science, 2020 - science.org
INTRODUCTION A reference atlas of human cell types is a major goal for the field. Here, we
set out to generate single-cell atlases of both gene expression (this study) and chromatin …

High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing: specific cell subtypes influence survival and determine molecular subtype …

S Olbrecht, P Busschaert, J Qian, A Vanderstichele… - Genome Medicine, 2021 - Springer
Background High-grade serous tubo-ovarian cancer (HGSTOC) is characterised by
extensive inter-and intratumour heterogeneity, resulting in persistent therapeutic resistance …

Intestinal lymphatic vasculature: structure, mechanisms and functions

J Bernier-Latmani, TV Petrova - Nature reviews Gastroenterology & …, 2017 - nature.com
The mammalian intestine is richly supplied with lymphatic vasculature, which has functions
ranging from maintenance of interstitial fluid balance to transport of antigens, antigen …

Interaction of tumor cells and lymphatic vessels in cancer progression

A Alitalo, M Detmar - Oncogene, 2012 - nature.com
Metastatic spread of cancer through the lymphatic system affects hundreds of thousands of
patients yearly. Growth of new lymphatic vessels, lymphangiogenesis, is activated in cancer …

Lymphatic vascular morphogenesis in development, physiology, and disease

S Schulte-Merker, A Sabine, TV Petrova - Journal of Cell Biology, 2011 - rupress.org
The lymphatic vasculature constitutes a highly specialized part of the vascular system that is
essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune …

Regulation of endothelial cell differentiation and specification

KL Marcelo, LC Goldie, KK Hirschi - Circulation research, 2013 - Am Heart Assoc
The circulatory system is the first organ system to develop in the vertebrate embryo and is
critical throughout gestation for the delivery of oxygen and nutrients to, as well as removal of …

Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth

M Guo, Y Du, JJ Gokey, S Ray, SM Bell, M Adam… - Nature …, 2019 - nature.com
The respiratory system undergoes a diversity of structural, biochemical, and functional
changes necessary for adaptation to air breathing at birth. To identify the heterogeneity of …

Development of the mammalian lymphatic vasculature

Y Yang, G Oliver - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
The two vascular systems of our body are the blood and lymphatic vasculature. Our
understanding of the cellular and molecular processes controlling the development of the …