5-Ene-4-thiazolidinones–An efficient tool in medicinal chemistry

D Kaminskyy, A Kryshchyshyn, R Lesyk - European journal of medicinal …, 2017 - Elsevier
The presented review is an attempt to summarize a huge volume of data on 5-ene-4-
thiazolidinones being a widely studied class of small molecules used in modern organic and …

Antitubercular properties of thiazolidin-4-ones–A review

N Trotsko - European Journal of Medicinal Chemistry, 2021 - Elsevier
Thiazolidin-4-one scaffold has great potential for medicinal chemistry and is of interest to
scientists in view of wide spectrum of biological activity. This scaffold is often used for …

Targeting amino acid metabolism of Mycobacterium tuberculosis for developing inhibitors to curtail its survival

SD Yelamanchi, A Surolia - IUBMB life, 2021 - Wiley Online Library
Tuberculosis caused by the bacterium, Mycobacterium tuberculosis (Mtb), continues to
remain one of the most devastating infectious diseases afflicting humans. Although there are …

Inhibitors of the sulfur assimilation pathway in bacterial pathogens as enhancers of antibiotic therapy

B Campanini, M Pieroni, S Raboni… - Current medicinal …, 2015 - ingentaconnect.com
The rising emergence of antibiotic resistance urges the search for new strategies to defeat
microorganisms that lead to persistent infections of the host. Tolerant to antibiotics, slowly …

Synthesis of diheteroatomic five‐membered heterocyclic compounds from α, β‐unsaturated aldehydes

NA Keiko, NV Vchislo - Asian Journal of Organic Chemistry, 2016 - Wiley Online Library
The recent increase in interest in the chemistry of azoles has been owing to their paramount
importance in several essential fields of research, such as pharmacology, medicine, biology …

Synthesis of Multifunctionalized Thiazolidine‐4‐thiones via [2+2+1] Annulation of Isothiocyanates and CF3‐Imidoyl Sulfoxonium Ylides

Y Ding, H Guo, J Fan, Z Li… - Advanced Synthesis & …, 2023 - Wiley Online Library
Iminothiazolidin‐4‐one, 5‐ethylidenethiazolidin‐4‐one, and thiazolidine‐4‐thione are all
medicinally relevant structures. In this work, a NaSO2CF3‐promoted [2+ 2+ 1] cascade …

Combatting antimicrobial resistance via the cysteine biosynthesis pathway in bacterial pathogens

JL Hicks, KEA Oldham, J McGarvie… - Bioscience …, 2022 - portlandpress.com
Antibiotics are the cornerstone of modern medicine and agriculture, and rising antibiotic
resistance is one the biggest threats to global health and food security. Identifying new and …

[HTML][HTML] Isozyme-Specific Ligands for O-acetylserine sulfhydrylase, a Novel Antibiotic Target

F Spyrakis, R Singh, P Cozzini, B Campanini, E Salsi… - PLoS …, 2013 - journals.plos.org
The last step of cysteine biosynthesis in bacteria and plants is catalyzed by O-acetylserine
sulfhydrylase. In bacteria, two isozymes, O-acetylserine sulfhydrylase-A and O-acetylserine …

Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery

VP Waman, SC Vedithi, SE Thomas… - Emerging microbes & …, 2019 - Taylor & Francis
Of the more than 190 distinct species of Mycobacterium genus, many are economically and
clinically important pathogens of humans or animals. Among those mycobacteria that infect …

Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis

K Brunner, S Maric, RS Reshma… - Journal of Medicinal …, 2016 - ACS Publications
Cysteine is an important amino acid in the redox defense of Mycobacterium tuberculosis,
primarily as a building block of mycothiol. Genetic studies have implicated de novo cysteine …