Since the discovery of SNARE proteins in the late 1980s, SNAREs have been recognized as
key components of protein complexes that drive membrane fusion. Despite considerable …

The release of neurotransmitters by Ca2+-triggered synaptic vesicle exocytosis is an
exquisitely regulated process that is fundamental for interneuronal communication. This …

It has been fifty years since the discovery that Ca2+ triggers the rapid exocytosis of
neurotransmitters from neurons. One of the proteins that has a crucial role in this secretion …

Paroxysmal kinesigenic dyskinesia with infantile convulsions (PKD/IC) is an episodic
movement disorder with autosomal-dominant inheritance and high penetrance, but the …

▪ Abstract The SNARE superfamily has become, since its discovery approximately a decade
ago, the most intensively studied element of the protein machinery involved in intracellular …

Membrane fusion occurs when SNAREpins fold up between lipid bilayers. How much
energy is generated during SNAREpin folding and how this energy is coupled to the fusion …

To characterize Ca 2+-mediated synaptic vesicle fusion, we analyzed Drosophila
synaptotagmin I mutants deficient in specific interactions mediated by its two Ca 2+ binding …

During exocytosis a four‐helical coiled coil is formed between the three SNARE proteins
syntaxin, synaptobrevin and SNAP‐25, bridging vesicle and plasma membrane. We have …

Synaptotagmin acts as a Ca2+ sensor in neurotransmitter release through its two C2
domains. Ca2+-dependent phospholipid binding is key for synaptotagmin function, but it is …

The discovery that Ca 2+ triggers rapid neurotransmitter release has prompted the search
for the Ca 2+ sensor. There is now general agreement that the vesicle-associated Ca 2+ …