Harnessing deep learning for population genetic inference

X Huang, A Rymbekova, O Dolgova, O Lao… - Nature Reviews …, 2024 - nature.com
In population genetics, the emergence of large-scale genomic data for various species and
populations has provided new opportunities to understand the evolutionary forces that drive …

Inference of population genetics parameters using discriminator neural networks: an adversarial Monte Carlo approach

G Gower, PI Picazo, F Lindgren, F Racimo - bioRxiv, 2023 - biorxiv.org
Accurately estimating biological variables of interest, such as parameters of demographic
models, is a key problem in evolutionary genetics. Likelihood-based and likelihood-free …

[HTML][HTML] Tree sequences as a general-purpose tool for population genetic inference

LS Whitehouse, D Ray, DR Schrider - bioRxiv, 2024 - ncbi.nlm.nih.gov
As population genetics data increases in size new methods have been developed to store
genetic information in efficient ways, such as tree sequences. These data structures are …

Latent generative modeling of long genetic sequences with GANs

A Szatkownik, C Furtlehner, G Charpiat, B Yelmen… - bioRxiv, 2024 - biorxiv.org
Synthetic data generation via generative modeling has recently become a prominent
research field in genomics, with applications ranging from functional sequence design to …

Statistical Inference Using Identity-by-Descent Segments: Perspectives on Recent Positive Selection

SD Temple - 2024 - search.proquest.com
Positive selection is suggested to be the primary mechanism of phenotypic adaptation.
Selective sweeps are one model of positive selection in which beneficial mutations increase …