The introduction of in vitro nucleic acid amplification techniques, led by real-time PCR, into
the clinical microbiology laboratory has transformed the laboratory detection of viruses and …

Septic syndromes represent a major although largely underrecognized healthcare problem
worldwide, accounting for thousands of deaths every year. It is now agreed that sepsis …

Although several dozen studies of gene expression in sepsis have been published,
distinguishing sepsis from a sterile systemic inflammatory response syndrome (SIRS) is still …

Rationale: Community-acquired pneumonia (CAP) accounts for a major proportion of
intensive care unit (ICU) admissions for respiratory failure and sepsis. Diagnostic uncertainty …

Purpose To quantify the effects of minor variations in the definition and measurement of
systemic inflammatory response syndrome (SIRS) criteria and organ failure on the observed …

Background: Mitochondrial transplantation is a promising strategy for the treatment of
several diseases. However, the effects of mitochondrial transplantation on the outcome of …

The high failure rate of therapeutics showing promise in mouse models to translate to
patients is a pressing challenge in biomedical science. Though retrospective studies have …

Background Diagnosis of acute infection in the critically ill remains a challenge. We
hypothesized that circulating leukocyte transcriptional profiles can be used to monitor the …

Introduction Sepsis engenders distinct host immunologic changes that include the
expansion of myeloid-derived suppressor cells (MDSCs). These cells play a physiologic role …

Study design Blood samples for microarray analysis were obtained from two groups of SLE
subjects (acutely ill SLE, inactive SLE) and healthy controls matched for age, gender and …