Furin‐mediated protein processing in infectious diseases and cancer
E Braun, D Sauter - Clinical & translational immunology, 2019 - Wiley Online Library
Proteolytic cleavage regulates numerous processes in health and disease. One key player
is the ubiquitously expressed serine protease furin, which cleaves a plethora of proteins at …
is the ubiquitously expressed serine protease furin, which cleaves a plethora of proteins at …
Cathepsin L in COVID-19: from pharmacological evidences to genetics
CP Gomes, DE Fernandes, F Casimiro… - Frontiers in cellular …, 2020 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemics is a challenge without precedent for
the modern science. Acute Respiratory Discomfort Syndrome (ARDS) is the most common …
the modern science. Acute Respiratory Discomfort Syndrome (ARDS) is the most common …
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
Abstract In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan,
China. Its genome has been sequenced and the genomic information promptly released …
China. Its genome has been sequenced and the genomic information promptly released …
Distinctive roles of furin and TMPRSS2 in SARS-CoV-2 infectivity
R Essalmani, J Jain, D Susan-Resiga… - Journal of …, 2022 - Am Soc Microbiol
The spike protein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
directs infection of the lungs and other tissues following its binding to the angiotensin …
directs infection of the lungs and other tissues following its binding to the angiotensin …
Evolutionary history, potential intermediate animal host, and cross‐species analyses of SARS‐CoV‐2
X Li, J Zai, Q Zhao, Q Nie, Y Li, BT Foley… - Journal of medical …, 2020 - Wiley Online Library
To investigate the evolutionary history of the recent outbreak of severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) in China, a total of 70 genomes of virus strains from …
syndrome coronavirus 2 (SARS‐CoV‐2) in China, a total of 70 genomes of virus strains from …
The biology and therapeutic targeting of the proprotein convertases
NG Seidah, A Prat - Nature reviews Drug discovery, 2012 - nature.com
The mammalian proprotein convertases constitute a family of nine secretory serine
proteases that are related to bacterial subtilisin and yeast kexin. Seven of these (proprotein …
proteases that are related to bacterial subtilisin and yeast kexin. Seven of these (proprotein …
Short linear motifs: ubiquitous and functionally diverse protein interaction modules directing cell regulation
K Van Roey, B Uyar, RJ Weatheritt, H Dinkel… - Chemical …, 2014 - ACS Publications
The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …
mediate the functions required for cell viability. Specific, context-dependent and tightly …
Native‐like Env trimers as a platform for HIV‐1 vaccine design
RW Sanders, JP Moore - Immunological reviews, 2017 - Wiley Online Library
We describe the development and potential use of various designs of recombinant HIV‐1
envelope glycoprotein trimers that mimic the structure of the virion‐associated spike, which …
envelope glycoprotein trimers that mimic the structure of the virion‐associated spike, which …
Furin at the cutting edge: from protein traffic to embryogenesis and disease
G Thomas - Nature reviews Molecular cell biology, 2002 - nature.com
Furin catalyses a simple biochemical reaction—the proteolytic maturation of proprotein
substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and …
substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and …
An updated insight into the molecular pathogenesis, secondary complications and potential therapeutics of COVID-19 pandemic
Abstract Coronavirus disease 2019 (COVID-19) is an unprecedented disease caused by
highly pathogenic SARS-CoV-2 and characterized by extreme respiratory deterrence …
highly pathogenic SARS-CoV-2 and characterized by extreme respiratory deterrence …