The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

Short-chain fatty acids (SCFAs) are the main metabolites produced by the bacterial
fermentation of dietary fiber, and they play a critical role in the maintenance of intestinal …

The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss
of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT …

Gut microbiota dysbiosis is closely involved in intestinal carcinogenesis. A marked reduction
in butyrate-producing bacteria has been observed in patients with colorectal cancer (CRC); …

Background Dysregulation of the epitranscriptome causes abnormal expression of
oncogenes in the tumorigenic process. Previous studies have shown that NAT10 can …

The Wnt/β-catenin signaling pathway is a growth control pathway involved in various
biological processes as well as the development and progression of cancer. Colorectal …

Abstract β‐catenin‐mediated Wnt signaling is an ancient cell‐communication pathway in
which β‐catenin drives the expression of certain genes as a consequence of the trigger …

Right-sided (proximal) colorectal cancer (CRC) has a poor prognosis and a distinct
mutational profile, characterized by oncogenic BRAF mutations and aberrations in mismatch …

KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant
problem for∼ 40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis …

The Wnt/β-catenin signaling pathway has been implicated as the central mechanism that
drives colorectal carcinogenesis. Its activation is historically due to mutation on APC …