The development of ruthenium (II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

FE Poynton, SA Bright, S Blasco, DC Williams… - Chemical Society …, 2017 - pubs.rsc.org
Ruthenium (II)[Ru (II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years …

Review of aquatic toxicity of pharmaceuticals and personal care products to algae

X Xin, G Huang, B Zhang - Journal of hazardous materials, 2021 - Elsevier
Abstract Pharmaceuticals and Personal Care Products (PPCPs) have been frequently
detected in the environment around the world. Algae play a significant role in aquatic …

Manganese‐Catalyzed Hydrogen‐Autotransfer C− C Bond Formation: α‐Alkylation of Ketones with Primary Alcohols

M Peña‐López, P Piehl, S Elangovan… - Angewandte …, 2016 - Wiley Online Library
A novel catalytic hydrogen‐autotransfer protocol for the atom‐efficient α‐alkylation of
ketones with readily available alcohols is presented. The use of manganese complexes …

TiO2 assisted photocatalysts for degradation of emerging organic pollutants in water and wastewater

HK Paumo, S Dalhatou, LM Katata-Seru… - Journal of Molecular …, 2021 - Elsevier
The occurrence of emerging organic pollutants (EOPs) in the aquatic environment
originating from point and diffuse sources, has been the subject of global apprehension in …

[PDF][PDF] Validation of QSAR models-strategies and importance

R Veerasamy, H Rajak, A Jain, S Sivadasan… - Int. J. Drug Des …, 2011 - researchgate.net
Quantitative Structure-Activity Relationship (QSAR) is based on the hypothesis that changes
in molecular structure reflect changes in the observed response or biological activity. The …

Toxicity testing in the 21st century: a vision and a strategy

D Krewski, D Acosta Jr, M Andersen… - Journal of Toxicology …, 2010 - Taylor & Francis
With the release of the landmark report Toxicity Testing in the 21st Century: A Vision and a
Strategy, the US National Academy of Sciences, in 2007, precipitated a major change in the …

[图书][B] Toxicity testing in the 21st century: a vision and a strategy

National Research Council, Division on Earth… - 2007 - books.google.com
Advances in molecular biology and toxicology are paving the way for major improvements in
the evaluation of the hazards posed by the large number of chemicals found at low levels in …

Flavonoid interactions during digestion, absorption, distribution and metabolism: A sequential structure–activity/property relationship-based approach in the study of …

GB Gonzales, G Smagghe, C Grootaert… - Drug metabolism …, 2015 - Taylor & Francis
Flavonoids are a group of polyphenols that provide health-promoting benefits upon
consumption. However, poor bioavailability has been a major hurdle in their use as drugs or …

Modes of action in ecotoxicology: their role in body burdens, species sensitivity, QSARs, and mixture effects

BI Escher, JLM Hermens - Environmental science & technology, 2002 - ACS Publications
In contrast to the general research attitude in the basic sciences, environmental sciences are
often goal-driven and should provide the scientific basis for risk assessment procedures …

Mechanisms of action for small molecules revealed by structural biology in drug discovery

Q Li, CB Kang - International journal of molecular sciences, 2020 - mdpi.com
Small-molecule drugs are organic compounds affecting molecular pathways by targeting
important proteins. These compounds have a low molecular weight, making them penetrate …