Interferon (IFN) signaling induces the expression of a wide array of genes, collectively
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …

Crimean-Congo hemorrhagic fever (CCHF) has the most extensive geographic range of the
medically significant tick-borne viruses, occurring from western China across southern Asia …

Interferon (IFN) stimulates a whole repertoire of cellular genes, collectively referred to as
ISGs (Interferon-stimulated genes). ISG20, a 3´-5´ exonuclease enzyme, has been …

Interferons (IFNs) are key mediators of the host innate antiviral immune response. To identify
IFN-stimulated genes (ISGs) that instigate an antiviral state against two medically important …

The goal of this study was to elucidate the molecular mechanism by which type I IFN inhibits
assembly and release of HIV-1 virions. Our study revealed that the IFN-induced ubiquitin …

Hepatitis C virus (HCV) infection is a common cause of chronic hepatitis and is currently
treated with alpha interferon (IFN-α)-based therapies. However, the underlying mechanism …

Alpha/beta interferon (IFN-α/β) produces antiviral effects through upregulation of many
interferon-stimulated genes (ISGs) whose protein products are effectors of the antiviral state …

Hepatitis B virus (HBV) replicates its DNA genome through reverse transcription of a viral
RNA pregenome. We report herein that the interferon (IFN) stimulated exoribonuclease …

Interferon‐stimulated gene 20 kDa protein (ISG20) is a relatively understudied antiviral
protein capable of inhibiting a broad spectrum of viruses. ISG20 exhibits strong RNase …

Intrinsic immunity describes the set of recently discovered but poorly understood cellular
mechanisms that specifically target viral pathogens. Their discovery derives in large part …