The nuclear factor erythroid 2 (NF-E2)-related factor 1 (NFE2L1, also known as Nrf1) is a
highly conserved transcription factor that belongs to the CNC-bZIP subfamily. Its significance …

The failure of the proper protein turnover in the nervous system is mainly linked to a variety
of neurodegenerative disorders. Therefore, a better understanding of key protein …

Proteasomes are the central proteolytic machines that are critical for breaking down most of
the damaged and abnormal proteins in human cells. Although universally applicable drugs …

Transcription factor Nrf1 acts as a unique vital player in maintaining cellular homeostasis
and organ integrity during normal development and growth throughout the life process. Loss …

Protein folding is a substantively error prone process, especially when it occurs in the
endoplasmic reticulum (ER). The highly exquisite machinery in the ER controls secretory …

The membrane-bound transcription factor Nrf1 (encoded by Nfe2l1) is activated by sensing
glucose deprivation, cholesterol abundance, proteasomal inhibition and oxidative stress and …

Protein-coding differences between species often fail to explain phenotypic diversity,
suggesting the involvement of genomic elements that regulate gene expression such as …

Neuroinflammation has been considered involved in the process of cerebral ischemia–
reperfusion injury (CIRI). Transcription factors play a crucial role in regulating gene …

Adipocytes play pivotal roles in maintaining energy homeostasis by storing lipids in adipose
tissue (AT), regulating the flux of lipids between AT and the circulation in response to the …

The corpus luteum (CL) is an important tissue of the female reproductive process which is
established through ovulation of the mature follicle. Pulsatile release of prostaglandin F2α …