Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

Acid‐sensing ion channels (ASICs) and the epithelial Na+ channel (ENaC) are both
members of the ENaC/degenerin family of amiloride‐sensitive Na+ channels. ASICs act as …

The mammalian distal convoluted tubule (DCT) makes an important contribution to
potassium homeostasis by modulating NaCl transport. The thiazide-sensitive Na+/Cl …

Background: MR (mineralocorticoid receptor) antagonists are recommended for patients
with resistant hypertension even when circulating aldosterone levels are not high. Although …

The identification of genes causing inherited kidney diseases yielded crucial insights in the
molecular basis of disease and improved our understanding of physiological processes that …

The role of Cl–as an intracellular signaling ion has been increasingly recognized in recent
years. One of the currently best described roles of Cl–in signaling is the modulation of the W …

Aldosterone exerts profound effects on renal and cardiovascular physiology. In the kidney,
aldosterone acts to preserve electrolyte and acid-base balance in response to changes in …

Molecular chaperones are responsible for maintaining cellular homeostasis, and one such
chaperone, GRP170, is an endoplasmic reticulum (ER) resident that oversees both protein …

Abstract Epithelial Na+ channels (ENaCs) control extracellular fluid volume by facilitating
Na+ absorption across transporting epithelia. In vitro studies showed that Cys-palmitoylation …

Oedema is a defining element of the nephrotic syndrome. Its' management varies
considerably between clinicians, with no national or international clinical guidelines, and …