The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that
trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the …

The intracellular calcium concentration ([Ca 2+]) has important roles in the triggering of
neurotransmitter release and the regulation of short-term plasticity (STP). Transmitter …

Pain after nerve damage is an expression of pathological operation of the nervous system,,
one hallmark of which is tactile allodynia—pain hypersensitivity evoked by innocuous …

Action potential timing is fundamental to information processing; however, its determinants
are not fully understood. Here we report unexpected structural specializations in the Ranvier …

Measles virus continues to be a major killer of children, claiming roughly one million lives a
year. Measles virus infection causes profound immunosuppression, which makes measles …

Sensory, motor and cortical neurons fire impulses or spikes at a regular, but slowly
declining, rate in response to a constant current stimulus. Yet, the intervals between spikes …

The present review examines the experimental evidence supporting the existence of central
mechanisms able to modulate the synaptic effectiveness of sensory fibers ending in the …

Synapse,” intended to contrast our grasp of presynaptic Angleson and Betz (1997) quite
recently reviewed in physiology with our understanding of postsynaptic detail techniques for …

Calcium-triggered fusion of synaptic vesicles and neurotransmitter release are fundamental
signalling steps in the central nervous system. It is generally assumed that fast transmitter …

The size of a pool of readily releasable vesicles at a giant brainstem synapse, the calyx of
Held, was probed with three independent approaches. Using simultaneous pre-and …