Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation

C Schiliro, BL Firestein - Cells, 2021 - mdpi.com
Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

The pentose phosphate pathway in yeasts–more than a poor cousin of glycolysis

LK Bertels, L Fernández Murillo, JJ Heinisch - Biomolecules, 2021 - mdpi.com
The pentose phosphate pathway (PPP) is a route that can work in parallel to glycolysis in
glucose degradation in most living cells. It has a unidirectional oxidative part with glucose-6 …

Metabolic reprogramming and its clinical implication for liver cancer

F Yang, L Hilakivi-Clarke, A Shaha, Y Wang, X Wang… - Hepatology, 2023 - journals.lww.com
Cancer cells often encounter hypoxic and hypo-nutrient conditions, which force them to
make adaptive changes to meet their high demands for energy and various biomaterials for …

[HTML][HTML] Preliminary study on impacts of polystyrene microplastics on the hematological system and gene expression in bone marrow cells of mice

R Sun, K Xu, L Yu, Y Pu, F Xiong, Y He… - Ecotoxicology and …, 2021 - Elsevier
Microplastics (MPs) are currently a global environmental pollutants and health hazards that
caused by MPs cannot be ignored. However, studies on MP toxicity in mammals are scare …

Anti-Warburg effect of melatonin: a proposed mechanism to explain its inhibition of multiple diseases

RJ Reiter, R Sharma, S Rosales-Corral - International journal of …, 2021 - mdpi.com
Glucose is an essential nutrient for every cell but its metabolic fate depends on cellular
phenotype. Normally, the product of cytosolic glycolysis, pyruvate, is transported into …

Ketogenic diet in the treatment of gliomas and glioblastomas

S Dal Bello, F Valdemarin, D Martinuzzi, F Filippi… - Nutrients, 2022 - mdpi.com
In recent years, scientific interest in the use of the ketogenic diet (KD) as a complementary
approach to the standard cancer therapy has grown, in particular against those of the central …

Moringa oleifera Lam. in Diabetes Mellitus: A Systematic Review and Meta-Analysis

S Watanabe, H Okoshi, S Yamabe, M Shimada - Molecules, 2021 - mdpi.com
Plant-derived phytochemicals have been interested in as nutraceuticals for preventing the
onset and progress of diabetes mellitus and its serious complications in recent years …

[HTML][HTML] PFKFB3-mediated pro-glycolytic shift in hepatocellular carcinoma proliferation

Q Dou, AK Grant, C Callahan, PC de Souza… - Cellular and Molecular …, 2023 - Elsevier
Background & Aims Metabolic reprogramming, in particular, glycolytic regulation, supports
abnormal survival and growth of hepatocellular carcinoma (HCC) and could serve as a …

Therapeutic drug-induced metabolic reprogramming in glioblastoma

TTT Nguyen, E Shang, MA Westhoff, G Karpel-Massler… - Cells, 2022 - mdpi.com
Glioblastoma WHO IV (GBM), the most common primary brain tumor in adults, is a
heterogenous malignancy that displays a reprogrammed metabolism with various fuel …

Monitoring intracellular pH fluctuation with an excited-state intramolecular proton transfer-based ratiometric fluorescent sensor

B Feng, Y Zhu, J Wu, X Huang, R Song, L Huang… - Chinese Chemical …, 2021 - Elsevier
Intracellular pH is a key parameter related to various biological and pathological processes.
In this study, a ratiometric pH fluorescent sensor ABTT was developed harnessing the amino …