The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for
cellular homeostasis and adaption to stress. Accumulating evidence indicates that …

The effects of acute sleep deprivation on β-amyloid (Aβ) clearance in the human brain have
not been documented. Here we used PET and 18F-florbetaben to measure brain Aβ burden …

Alzheimer's disease (AD) is currently untreatable, and therapeutic strategies aimed to slow
cognitive decline have not yet been successful. Many of these approaches have targeted the …

Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of
death in the US. The neuropathological hallmarks of the disease are extracellular amyloid-β …

Objective Astrocytes fulfill neuronal trophic roles normally, but are transformed in Alzheimer
disease (AD) into A1‐type reactive astrocytes that may destroy neurons through unknown …

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's …

As the size of genome-wide association studies increase, the number of associated trait loci
identified inevitably increase. One welcomes this if it allows the better delineation of the …

Alzheimer's disease (AD) is an age-associated neurodegenerative disease characterized by
amyloidosis, tauopathy, and activation of microglia, the brain resident innate immune cells …

The diseased brain hosts a heterogeneous population of myeloid cells, including
parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne …