Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Alzheimer's disease (AD) is a neurodegenerative disorder with devastating symptoms,
including memory impairments and cognitive deficits. Hallmarks of AD pathology are …

In Alzheimer's disease, fibrillar tau pathology accumulates and spreads through the brain
and synapses are lost. Evidence from mouse models indicates that tau spreads trans …

Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …

Background Synapse damage and loss are fundamental to the pathophysiology of
Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is to …

Alzheimer's Disease (AD) is a chronic neurodegenerative disorder and the most common
type of dementia (60–80% of cases). In 2016, nearly 44 million people were affected by AD …

Alzheimer's disease (AD) is characterized by memory loss, cognitive decline, and
devastating neurodegeneration, not only as a result of the extracellular accumulation of beta …

Accumulation of misfolded and aggregated forms of tau protein in the brain is a
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …

The microtubule-associated protein tau and amyloid-β (Aβ) are key players in Alzheimer's
disease (AD). Aβ and tau are linked in a molecular pathway at the post-synapse with tau …

Alzheimer's disease (AD) is defined by the presence of intraneuronal neurofibrillary tangles
(NFTs) composed of hyperphosphorylated tau aggregates as well as extracellular amyloid …