For the past three decades, the use of genomics to inform drug discovery and development
pipelines has generated both excitement and scepticism. Although earlier efforts …

Anthropogenic increases in fossil fuel emissions have been a primary driver of increased
concentrations of atmospheric carbon dioxide ([CO 2]) and other greenhouse gases …

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …

Over the past 5 years, genomewide association studies have yielded a wealth of insight into
genes and chromosomal loci that contribute to susceptibility to disease. This article, the …

Although we have studied schizophrenia as a major disease entity over the past century, its
causes and pathogenesis remain obscure. In this article, we critically review genetic and …

Chip-based high-throughput genotyping has facilitated genome-wide studies of genetic
diversity. Many studies have utilized these large data sets to make inferences about the …

Major depressive disorder (MDD) is a highly prevalent disorder with substantial heritability.
Heritability has been shown to be substantial and higher in the variant of MDD characterized …

Soybean is the world's leading source of vegetable protein and demand for its seed
continues to grow. Breeders have successfully increased soybean yield, but the genetic …

Family, twin and adoption studies demonstrate clearly that alcohol dependence and alcohol
use disorders are phenotypically complex and heritable. The heritability of alcohol use …

Metabolomics is the untargeted measurement of the metabolome, which is composed of the
complement of small molecules detected in a biological sample. As such, metabolomic …