Vimentin is at the heart of epithelial mesenchymal transition (EMT) mediated metastasis

S Usman, NH Waseem, TKN Nguyen, S Mohsin… - Cancers, 2021 - mdpi.com
Simple Summary Vimentin is an important filamentous protein providing structural and
functional support to the cell. During initial stages of cancer development, vimentin …

Novel therapeutic strategies: Targeting epithelial–mesenchymal transition in colorectal cancer

N Zhang, AS Ng, S Cai, Q Li, L Yang, D Kerr - The lancet oncology, 2021 - thelancet.com
Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial
characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain …

The cytoskeleton—a complex interacting meshwork

T Hohmann, F Dehghani - Cells, 2019 - mdpi.com
The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Vimentin and cytokeratin: Good alone, bad together

NA Kuburich, P den Hollander, JT Pietz… - Seminars in cancer …, 2022 - Elsevier
The cytoskeleton plays an integral role in maintaining the integrity of epithelial cells.
Epithelial cells primarily employ cytokeratin in their cytoskeleton, whereas mesenchymal …

Vimentin intermediate filaments as potential target for cancer treatment

K Strouhalova, M Přechová, A Gandalovičová… - Cancers, 2020 - mdpi.com
Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …

Vimentin: Regulation and pathogenesis

D Paulin, A Lilienbaum, S Kardjian, O Agbulut, Z Li - Biochimie, 2022 - Elsevier
Vimentin, an abundant cytoplasmic intermediate filament protein, is recognized for its
important role in stabilizing intracellular structure. Vimentin has been recognized for its …

TGF-β1 signalling in Alzheimer's pathology and cytoskeletal reorganization: a specialized Tau perspective

M Kapoor, S Chinnathambi - Journal of Neuroinflammation, 2023 - Springer
Microtubule-associated protein, Tau has been implicated in Alzheimer's disease for its
detachment from microtubules and formation of insoluble intracellular aggregates within the …

Vimentin as a multifaceted player and potential therapeutic target in viral infections

I Ramos, K Stamatakis, CL Oeste… - International journal of …, 2020 - mdpi.com
Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal
functions, and therefore in basic cellular processes such as cell division and migration …

Vimentin at the core of wound healing

LS Coelho-Rato, S Parvanian, MK Modi… - Trends in Cell Biology, 2024 - cell.com
As a member of the large family of intermediate filaments (IFs), vimentin has emerged as a
highly dynamic and versatile cytoskeletal protein involved in many key processes of wound …

Impact of vimentin on regulation of cell signaling and matrix remodeling

Z Ostrowska-Podhorodecka, I Ding… - Frontiers in Cell and …, 2022 - frontiersin.org
Vimentin expression contributes to cellular mechanoprotection and is a widely recognized
marker of fibroblasts and of epithelial-mesenchymal transition. But it is not understood how …