The global spread of drug resistance in bacteria requires new potent and safe antimicrobial
agents. Compounds containing the 1, 2, 4-triazole ring in their structure are characterised by …

Bacterial infections represent a significant health threat globally, and are responsible for the
majority of hospital-acquired infections, leading to extensive mortality and burden on global …

Antibiotics are commonly used to fight against bacterial infections, but bacteria have already
been resistant to almost all antibiotics due to abuse of antibiotics. 1, 2, 4-Triazole derived …

Quinoline and quinolone motifs which act as structural subunits of more complex natural
products are ubiquitous in nature, and they are useful pharmacophores which play a pivotal …

Fluoroquinolones remain one of the most important kind of antibacterial agents used
nowadays. The emergence of more virulent and resistant strains of bacteria by the …

Bacterial infections, caused predominately by Gram-positive and Gram-negative organisms,
are proliferation of harmful strains of bacteria on or inside the body. Hospital-acquired and …

Hybridization, a strategy based on the covalent fusion of two or more existing
pharmacophores to create a single molecule with multiple mechanisms of action, represents …

QSAR modeling was performed on 39 quinolone-triazole derivatives against gram-positive
Staphylococcus aureus and gram-negative Pseudomonas aeruginosa bacteria. The …

Puerarin is an important active ingredient of Radix puerariae. Puerarin is an isoflavone
compound Z clinical and basic research proves that S. puerarin can increase cerebral …

Triazoles are five-membered aromatic heterocyclics, which exhibit two isosteric forms (1, 2, 3-
triazoles and 1, 2, 4-triazoles), as well as multiple applications in medicinal, agricultural …