Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Rising incidence of early-onset colorectal cancer—A call to action

N Akimoto, T Ugai, R Zhong, T Hamada… - Nature reviews Clinical …, 2021 - nature.com
The incidence of early-onset colorectal cancer (CRC), which occurs in individuals< 50 years
of age, has been increasing worldwide and particularly in high-income countries. The …

Genetic impacts on DNA methylation: research findings and future perspectives

S Villicaña, JT Bell - Genome biology, 2021 - Springer
Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …

Risk assessment of aflatoxins in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2020 - Wiley Online Library
EFSA was asked to deliver a scientific opinion on the risks to public health related to the
presence of aflatoxins in food. The risk assessment was confined to aflatoxin B1 (AFB 1) …

Green chemistry as just chemistry

MKM Lane, HE Rudel, JA Wilson, HC Erythropel… - Nature …, 2023 - nature.com
Environmental injustices have exposed our current system of reliance on polluting and toxic
chemicals and chemistries as untenable and one whose risks and burdens are …

Risk assessment of ochratoxin A in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2020 - Wiley Online Library
Abstract The European Commission asked EFSA to update their 2006 opinion on ochratoxin
A (OTA) in food. OTA is produced by fungi of the genus Aspergillus and Penicillium and …

Understanding health inequalities through the lens of social epigenetics

CL Martin, L Ghastine, EK Lodge… - Annual review of …, 2022 - annualreviews.org
Longstanding racial/ethnic inequalities in morbidity and mortality persist in the United States.
Although the determinants of health inequalities are complex, social and structural factors …

Genetic contributions to autism spectrum disorder

A Havdahl, M Niarchou, A Starnawska… - Psychological …, 2021 - cambridge.org
Autism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental
conditions characterized by early childhood-onset impairments in communication and social …

Overweight and obesity in pregnancy: their impact on epigenetics

C Reichetzeder - European journal of clinical nutrition, 2021 - nature.com
Over the last few decades, the prevalence of obesity has risen to epidemic proportions
worldwide. Consequently, the number of obesity in pregnancy has risen drastically …

Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?

ND Saenen, DS Martens, KY Neven, R Alfano… - Clinical …, 2019 - Springer
Abstract According to the “Developmental Origins of Health and Disease”(DOHaD) concept,
the early-life environment is a critical period for fetal programming. Given the …