Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …

Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor prognosis and
limited treatment options. Here we provide a comprehensive census of the bone marrow …

Age-related clonal hematopoiesis (CH) is a risk factor for malignancy, cardiovascular
disease, and all-cause mortality. Somatic mutations in DNMT3A are drivers of CH, but …

A major obstacle in the treatment of acute myeloid leukemia (AML) is refractory disease or
relapse after achieving remission. The latter arises from a few therapy-resistant cells within …

Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …

With a growing aged population, there is an imminent need to develop new therapeutic
strategies to ameliorate disorders of hematopoietic aging, including clonal hematopoiesis …

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …

Characterized by the accumulation of somatic mutations in blood cell lineages, clonal
hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the …

Recent advances have highlighted the ability of hematopoietic stem and progenitor cells in
the bone marrow to sense peripheral inflammation or infection and adapt through increased …