We present the inhibitory properties of the R. pompana anthocyanin fraction (RPAF) and its
major constituents on alpha‐glucosidase (AG), pancreatic lipase (PL), HMG‐CoA reductase …

The cause of death in most breast cancer patients is disease metastasis and the occurrence
of multidrug resistance (MDR). Ornithine decarboxylase (ODC), which is involved into …

Pyridoxal 5′-phosphate (PLP)-dependent enzymes are found ubiquitously in nature and
are involved in a variety of biological pathways, from natural product synthesis to amino acid …

This perspective delves into the investigation of synthetic and naturally occurring inhibitors,
their patterns of inhibition, and the effectiveness of newly utilized natural compounds as …

Background Polyamines play important roles in cell growth and proliferation. Polyamine
metabolism genes are dysregulated in various tumors. Some polyamine metabolism genes …

Backgrounds Polyamine metabolism (PM) is closely related to the tumor microenvironment
(TME) and is involved in antitumor immunity. Clear cell renal cell carcinoma (ccRCC) not …

Polyamines (PAs) play an important regulatory role in many basic cellular processes and
physiological and biochemical processes. However, there are few studies on the …

Personized treatment of breast cancer is still a challenge, and more treatment options for
breast cancer are warranted. Combination therapies have been a highly appreciated …

Ornithine decarboxylase (ODC) catalyzes the decarboxylation of ornithine to produce
putrescine, the first step in the metabolism of polyamines (putrescine, spermidine, and …

Targeted covalent inhibitors (TCIs) form covalent bonds with targets following initial non-
covalent binding. The advantages of TCIs have driven a resurgence in rational TCI design …