The role of microglia in diabetic retinopathy: inflammation, microvasculature defects and neurodegeneration

C Altmann, MHH Schmidt - International journal of molecular sciences, 2018 - mdpi.com
Diabetic retinopathy is a common complication of diabetes mellitus, which appears in one
third of all diabetic patients and is a prominent cause of vision loss. First discovered as a …

Microglia in the retina: roles in development, maturity, and disease

SM Silverman, WT Wong - Annual review of vision science, 2018 - annualreviews.org
Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …

Retinal microglia: just bystander or target for therapy?

M Karlstetter, R Scholz, M Rutar, WT Wong… - Progress in retinal and …, 2015 - Elsevier
Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …

Physiology of microglia

H Kettenmann, UK Hanisch, M Noda… - Physiological …, 2011 - journals.physiology.org
Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Quantitating the subtleties of microglial morphology with fractal analysis

A Karperien, H Ahammer, HF Jelinek - Frontiers in cellular …, 2013 - frontiersin.org
It is well established that microglial form and function are inextricably linked. In recent years,
the traditional view that microglial form ranges between “ramified resting” and “activated …

Age‐related macular degeneration: new paradigms for treatment and management of AMD

LF Hernández-Zimbrón… - Oxidative medicine …, 2018 - Wiley Online Library
Age‐related macular degeneration (AMD) is a well‐characterized and extensively studied
disease. It is currently considered the leading cause of visual disability among patients over …

Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma

Y Miao, GL Zhao, S Cheng, Z Wang, XL Yang - Progress in retinal and eye …, 2023 - Elsevier
Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Microglia: biology and pathology

MB Graeber, WJ Streit - Acta neuropathologica, 2010 - Springer
The past 20 years have seen a gain in knowledge on microglia biology and microglia
functions in disease that exceeds the expectations formulated when the microglia “immune …

Retinal microglia–A key player in healthy and diseased retina

G Rathnasamy, WS Foulds, EA Ling, C Kaur - Progress in neurobiology, 2019 - Elsevier
Microglia, the resident immune cells of the brain and retina, are constantly engaged in the
surveillance of their surrounding neural tissue. During embryonic development they infiltrate …

Age‐related alterations in the dynamic behavior of microglia

MR Damani, L Zhao, AM Fontainhas, J Amaral… - Aging cell, 2011 - Wiley Online Library
Microglia, the primary resident immune cells of the central nervous system (CNS), exhibit
dynamic behavior involving rapid process motility and cellular migration that is thought to …