The ability to sense external temperature is assumed by somatosensory neurons, in which
temperature information is converted to neural activity by afferent input to the central nervous …

The regulation of body temperature is one of the most critical functions of the nervous
system. Here we review our current understanding of thermoregulation in mammals. We …

Distinct types of dorsal root ganglion sensory neurons may have unique contributions to
chronic pain. Identification of primate sensory neuron types is critical for understanding the …

Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Phenomena such as placebo analgesia or pain relief through distraction highlight the
powerful influence cognitive processes and learning mechanisms have on the way we …

The mammalian nervous system encodes many different forms of pain, from those that arise
as a result of short-term low-grade interactions with noxious thermal, chemical, or …

Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Our ability to perceive temperature is crucial: it enables us to swiftly react to noxiously cold or
hot objects and helps us to maintain a constant body temperature. Sensory nerve endings …

The original formulation of Gate Control Theory (GCT) proposed that the perception of pain
produced by spinal cord signaling to the brain depends on a balance of activity generated in …