Engineering universal cells that evade immune detection

R Lanza, DW Russell, A Nagy - Nature Reviews Immunology, 2019 - nature.com
The prospect of transplanting cells and tissues without the risk of immune rejection or the
need for powerful immunosuppressive drugs is the 'holy grail'of transplantation medicine …

The value of monitoring wildlife roadkill

ALW Schwartz, FM Shilling, SE Perkins - European journal of wildlife …, 2020 - Springer
The number of wildlife-vehicle collisions has an obvious value in estimating the direct effects
of roads on wildlife, ie mortality due to vehicle collisions. Given the nature of the data …

Centuries of genome instability and evolution in soft-shell clam, Myaarenaria, bivalve transmissible neoplasia

SFM Hart, MA Yonemitsu, RM Giersch, FES Garrett… - Nature Cancer, 2023 - nature.com
Transmissible cancers are infectious parasitic clones that metastasize to new hosts, living
past the death of the founder animal in which the cancer initiated. We investigated the …

Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule

AL Bruzos, M Santamarina, D Garcia-Souto, S Díaz… - Nature Cancer, 2023 - nature.com
Transmissible cancers are malignant cell lineages that spread clonally between individuals.
Several such cancers, termed bivalve transmissible neoplasia (BTN), induce leukemia-like …

The evolution of two transmissible cancers in Tasmanian devils

MR Stammnitz, K Gori, YM Kwon, E Harry, FJ Martin… - Science, 2023 - science.org
Tasmanian devils have spawned two transmissible cancer lineages, named devil facial
tumor 1 (DFT1) and devil facial tumor 2 (DFT2). We investigated the genetic diversity and …

The value of reference genomes in the conservation of threatened species

P Brandies, E Peel, CJ Hogg, K Belov - Genes, 2019 - mdpi.com
Conservation initiatives are now more crucial than ever—over a million plant and animal
species are at risk of extinction over the coming decades. The genetic management of …

[HTML][HTML] Rapid evolutionary response to a transmissible cancer in Tasmanian devils

B Epstein, M Jones, R Hamede, S Hendricks… - Nature …, 2016 - nature.com
Although cancer rarely acts as an infectious disease, a recently emerged transmissible
cancer in Tasmanian devils (Sarcophilus harrisii) is virtually 100% fatal. Devil facial tumour …

Widespread transmission of independent cancer lineages within multiple bivalve species

MJ Metzger, A Villalba, MJ Carballal, D Iglesias… - Nature, 2016 - nature.com
Most cancers arise from oncogenic changes in the genomes of somatic cells, and while the
cells may migrate by metastasis, they remain within that single individual. Natural …

Density trends and demographic signals uncover the long‐term impact of transmissible cancer in Tasmanian devils

BT Lazenby, MW Tobler, WE Brown… - Journal of Applied …, 2018 - Wiley Online Library
Monitoring the response of wild mammal populations to threatening processes is
fundamental to effective conservation management. This is especially true for infectious …

Quantifying 25 years of disease‐caused declines in Tasmanian devil populations: host density drives spatial pathogen spread

CX Cunningham, S Comte, H McCallum… - Ecology …, 2021 - Wiley Online Library
Infectious diseases are strong drivers of wildlife population dynamics, however, empirical
analyses from the early stages of pathogen emergence are rare. Tasmanian devil facial …