Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Cancer is one of the greatest public health challenges. According to the World Health
Organization (WHO), 9.6 million cancer deaths have been reported in 2018. The most …

Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our
appreciation for the complex roles for WNT signalling pathways in cancer has increased …

Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation,
proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many …

Proteases are crucial for development, tissue remodeling, and tumorigenesis. Matrix
metalloproteinases (MMPs) family, in particular, consists of more than 20 members with …

Cancer is one of the major causes of death worldwide. Its treatments usually fail when the
tumor has become malignant and metastasized. Metastasis is a key source of cancer …

Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that cleave nearly all
components of the extracellular matrix as well as many other soluble and cell‐associated …

Members of the matrix metalloproteinase (MMP) family have been identified as poor
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …

A series of luminescent iridium (III) complexes were synthesised and evaluated for their
ability to act as luminescent G-quadruplex-selective probes. The iridium (III) complex 9 [Ir …

Tissue regeneration after injury requires coordinated regulation of stem cell activation,
division, and daughter cell differentiation, processes that are increasingly well understood in …