Organ‐protective effects and the underlying mechanism of dexmedetomidine

N Bao, B Tang - Mediators of inflammation, 2020 - Wiley Online Library
Dexmedetomidine (DEX) is a highly selective α2 adrenergic receptor (α2AR) agonist
currently used in clinical settings. Because DEX has dose‐dependent advantages of …

Molecular mechanisms of cholinergic neurotransmission in visceral smooth muscles with a focus on receptor-operated TRPC4 channel and impairment of …

AV Zholos, MI Melnyk, DO Dryn - Neuropharmacology, 2024 - Elsevier
Acetylcholine is the primary excitatory neurotransmitter in visceral smooth muscles, wherein
it binds to and activates two muscarinic receptors subtypes, M 2 and M 3, thus causing …

Effect of dexmedetomidine on mortality and ventilator-free days in patients requiring mechanical ventilation with sepsis: a randomized clinical trial

Y Kawazoe, K Miyamoto, T Morimoto, T Yamamoto… - Jama, 2017 - jamanetwork.com
Importance Dexmedetomidine provides sedation for patients undergoing ventilation;
however, its effects on mortality and ventilator-free days have not been well studied among …

Effect of intraoperative dexmedetomidine on recovery of gastrointestinal function after abdominal surgery in older adults: a randomized clinical trial

Y Lu, PP Fang, YQ Yu, XQ Cheng, XM Feng… - JAMA network …, 2021 - jamanetwork.com
Importance Postoperative ileus is common after abdominal surgery, and small clinical
studies have reported that intraoperative administration of dexmedetomidine may be …

Dexmedetomidine improves gastrointestinal motility after laparoscopic resection of colorectal cancer: a randomized clinical trial

C Chen, P Huang, L Lai, C Luo, M Ge, Z Hei, Q Zhu… - Medicine, 2016 - journals.lww.com
Background: To investigate the effects of intraoperative application of dexmedetomidine
(Dex) on early gastrointestinal motility after laparoscopic resection of colorectal cancer …

Inhibitory Effects of Dexmedetomidine and Propofol on Gastrointestinal Tract Motility Involving Impaired Enteric Glia Ca2+ Response in Mice

Y Li, Y Wang, H Chang, B Cheng, J Miao, S Li… - Neurochemical …, 2021 - Springer
Propofol and dexmedetomidine are popular used for sedation in ICU, however, inadequate
attention has been paid to their effect on gastrointestinal tract (GIT) motility. Present study …

The effect of thymol on acetylcholine-induced contractions of the rat ileum and uterus under ex vivo conditions

B Premrov Bajuk, L Prem, T Vake… - Frontiers in …, 2022 - frontiersin.org
Thyme (Thymus vulgaris L.) is a well-known medicinal plant, the aerial parts of which have
long been used internally or externally as a traditional remedy for various diseases. Thyme …

Postoperative recovery of colorectal patients enhanced with dexmedetomidine (PReCEDex): a systematic review and meta-analysis of randomized controlled trials

S Sharma, J Khamar, JA Petropolous, A Ghuman - Surgical Endoscopy, 2024 - Springer
Background Intraoperative administration of dexmedetomidine has shown promise in
improving postoperative gastrointestinal function. In the context of colorectal surgery, the …

Epidural co-administration of dexmedetomidine and levobupivacaine improves the gastrointestinal motility function after colonic resection in comparison to co …

XZ Zeng, ZF Lu, XQ Lv, YP Guo, XG Cui - PLoS One, 2016 - journals.plos.org
Gastrointestinal motility may be impaired after intestinal surgery. Epidural morphine is
effective in controlling postoperative pain, but can further reduce gastrointestinal motility …

Dexmedetomidine Has Differential Effects on the Contractility of Equine Jejunal Smooth Muscle Layers in Vitro

N Verhaar, S Hoppe, AM Grages, K Hansen… - Animals, 2023 - mdpi.com
Simple Summary Alpha-2 agonists are commonly used sedatives in horses. They are known
for their inhibitive effects on gastrointestinal motility, which limits their use in horses with …