Artificial RNA translation modulation usually relies on multiple components, such as RNA
binding proteins (RBPs) or microRNAs (miRNAs) for off-switches and double-inverter …

So far, biocomputation strictly follows traditional design principles of digital electronics,
which could reach their limits when assembling gene circuits of higher complexity. Here, by …

Immunotherapy has shown robust efficacy in treating a broad spectrum of hematological and
solid cancers. Despite the transformative impact of immunotherapy on cancer treatment …

Highlights•Biocomputation refers to regulation of gene expression with machine-like
precision.•Computational networks can comprise single or multiple layers of regulation …

Effective systemic treatment for hepatocellular carcinoma (HCC) remains urgently needed.
Sorafenib is the first FDA-approved systemic treatment for HCC. However, individual HCC …

Objective The aim of this study is to evaluate an AAV vector that can selectively target breast
cancer cells and to investigate its specificity and anti-tumor effects on breast cancer cells …

Background This study investigates the molecular mechanisms of CC@ AC&SF@ PP NPs
loaded with AC099850. 3 siRNA and sorafenib (SF) for improving hepatitis B virus-related …

Simple Summary This study explored a potentially significant player in the spread of
metastatic cancer:“hybrid cells”(HCs) combining features of both epithelial (common in …

Limiting expression to target cell types is a longstanding goal in gene therapy, which could
be met by sensing endogenous microRNA. However, an unclear association between …

Background Hepatocholangiocarcinoma (H-ChC) has the clinicopathological features of
both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA) and is a …