COVID-19 is, in the end, an endothelial disease

P Libby, T Lüscher - European heart journal, 2020 - academic.oup.com
The vascular endothelium provides the crucial interface between the blood compartment
and tissues, and displays a series of remarkable properties that normally maintain …

Is COVID-19 a new hematologic disease?

B Debuc, DM Smadja - Stem cell reviews and reports, 2021 - Springer
SARS-CoV-2 viruses are positive single-stranded RNA viruses, whose infection can be
asymptomatic or lead to the coronavirus disease 2019 (Covid-19). Covid-19 is a respiratory …

Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients

DM Smadja, CL Guerin, R Chocron, N Yatim… - Angiogenesis, 2020 - Springer
Abstract Background Coronavirus disease-2019 (COVID-19), a respiratory disease has
been associated with ischemic complications, coagulation disorders, and an endotheliitis …

Efficient data-driven machine learning models for cardiovascular diseases risk prediction

E Dritsas, M Trigka - Sensors, 2023 - mdpi.com
Cardiovascular diseases (CVDs) are now the leading cause of death, as the quality of life
and human habits have changed significantly. CVDs are accompanied by various …

[HTML][HTML] Angiotensin II triggers release of neutrophil extracellular traps, linking thromboinflammation with essential hypertension

A Chrysanthopoulou, E Gkaliagkousi, A Lazaridis… - JCI insight, 2021 - ncbi.nlm.nih.gov
Innate immunity and chronic inflammation are involved in atherosclerosis and
atherothrombosis, leading to target organ damage in essential hypertension (EH). However …

Coagulation and complement: Key innate defense participants in a seamless web

ELG Pryzdial, A Leatherdale, EM Conway - Frontiers in immunology, 2022 - frontiersin.org
In 1969, Dr. Oscar Ratnoff, a pioneer in delineating the mechanisms by which coagulation is
activated and complement is regulated, wrote,“In the study of biological processes, the …

COVID-19–associated coagulopathy and inflammatory response: what do we know already and what are the knowledge gaps?

K Goerlinger, D Dirkmann, A Gandhi… - Anesthesia & …, 2020 - journals.lww.com
Patients with coronavirus disease 2019 (COVID-19) frequently experience a coagulopathy
associated with a high incidence of thrombotic events leading to poor outcomes. Here …

Endothelial dysfunction in COVID-19: a unifying mechanism and a potential therapeutic target

P Ambrosino, IL Calcaterra, M Mosella, R Formisano… - Biomedicines, 2022 - mdpi.com
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) generated a
worldwide emergency, until the declaration of the pandemic in March 2020. SARS-CoV-2 …

Monomeric C-reactive protein in atherosclerotic cardiovascular disease: advances and perspectives

I Melnikov, S Kozlov, O Saburova, Y Avtaeva… - International journal of …, 2023 - mdpi.com
This review aimed to trace the inflammatory pathway from the NLRP3 inflammasome to
monomeric C-reactive protein (mCRP) in atherosclerotic cardiovascular disease. CRP is the …

Oral anticoagulants beyond warfarin

RH Olie, K Winckers, B Rocca… - Annual Review of …, 2024 - annualreviews.org
Direct oral anticoagulants (DOACs) have largely replaced vitamin K antagonists, mostly
warfarin, for the main indications for oral anticoagulation, prevention and treatment of …