Most adaption processes have a polygenic genetic basis, but even with the recent explosive
growth of genomic data we are still lacking a unified framework describing the dynamics of …

The first decade of ancient genomics has revolutionized the study of human prehistory and
evolution. We review new insights based on prehistoric modern human genomes, including …

A historical tendency to use European ancestry samples hinders medical genetics research,
including the use of polygenic scores, which are individual-level metrics of genetic risk. We …

Fields as diverse as human genetics and sociology are increasingly using polygenic scores
based on genome-wide association studies (GWAS) for phenotypic prediction. However …

Genetic predictions of height differ among human populations and these differences have
been interpreted as evidence of polygenic adaptation. These differences were first detected …

Several recent papers have reported strong signals of selection on European polygenic
height scores. These analyses used height effect estimates from the GIANT consortium and …

Many traits of interest are highly heritable and genetically complex, meaning that much of
the variation they exhibit arises from differences at numerous loci in the genome. Complex …

Modern humans inhabit a variety of environments and are exposed to a plethora of selective
pressures, leading to multiple genetic adaptations to local environmental conditions. These …

Recent analyses of polygenic scores have opened new discussions concerning the genetic
basis and evolutionary significance of differences among populations in distributions of …

Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …