Making and breaking nucleic acids: two-Mg2+-ion catalysis and substrate specificity
W Yang, JY Lee, M Nowotny - Molecular cell, 2006 - cell.com
DNA and a large proportion of RNA are antiparallel duplexes composed of an unvarying
phosphosugar backbone surrounding uniformly stacked and highly similar base pairs. How …
phosphosugar backbone surrounding uniformly stacked and highly similar base pairs. How …
RNase H activity: structure, specificity, and function in reverse transcription
SJ Schultz, JJ Champoux - Virus research, 2008 - Elsevier
This review compares the well-studied RNase H activities of human immunodeficiency virus,
type 1 (HIV-1) and Moloney murine leukemia virus (MoMLV) reverse transcriptases. The …
type 1 (HIV-1) and Moloney murine leukemia virus (MoMLV) reverse transcriptases. The …
Human immunodeficiency virus type 1 nucleocapsid protein promotes efficient strand transfer and specific viral DNA synthesis by inhibiting TAR-dependent self …
J Guo, LE Henderson, J Bess, B Kane… - Journal of virology, 1997 - Am Soc Microbiol
During the first strand transfer in reverse transcription, minus-strand strong-stop DNA [(-)
SSDNA] is annealed to the 3'end of the acceptor RNA in a reaction mediated by base …
SSDNA] is annealed to the 3'end of the acceptor RNA in a reaction mediated by base …
Newly synthesized APOBEC3G is incorporated into HIV virions, inhibited by HIV RNA, and subsequently activated by RNase H
VB Soros, W Yonemoto, WC Greene - PLoS pathogens, 2007 - journals.plos.org
APOBEC3G (A3G) is a potent antiretroviral deoxycytidine deaminase that, when
incorporated into HIV virions, hypermutates nascent viral DNA formed during reverse …
incorporated into HIV virions, hypermutates nascent viral DNA formed during reverse …
HIV-1 reverse transcription: A brief overview focused on structure–function relationships among molecules involved in initiation of the reaction
M Götte, X Li, MA Wainberg - Archives of biochemistry and biophysics, 1999 - Elsevier
An early step in the life cycle of the human immunodeficiency virus type 1 (HIV-1) is reverse
transcription of viral RNA into proviral DNA, which can then be integrated into the host cell …
transcription of viral RNA into proviral DNA, which can then be integrated into the host cell …
The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase
HQ Gao, PL Boyer, SG Sarafianos, E Arnold… - Journal of molecular …, 2000 - Elsevier
Treating HIV infections with drugs that block viral replication selects for drug-resistant strains
of the virus. Particular inhibitors select characteristic resistance mutations. In the case of the …
of the virus. Particular inhibitors select characteristic resistance mutations. In the case of the …
Human immunodeficiency virus type 1 nucleocapsid protein reduces reverse transcriptase pausing at a secondary structure near the murine leukemia virus polypurine …
W Wu, LE Henderson, TD Copeland… - Journal of …, 1996 - Am Soc Microbiol
In an earlier study on minus-strand DNA synthesis catalyzed by murine leukemia virus
reverse transcriptase, we described a prominent pause site near the polypurine tract (J. Guo …
reverse transcriptase, we described a prominent pause site near the polypurine tract (J. Guo …
Poliovirus RNA-dependent RNA polymerase (3Dpol): divalent cation modulation of primer, template, and nucleotide selection
JJ Arnold, SKB Ghosh, CE Cameron - Journal of Biological Chemistry, 1999 - ASBMB
We have analyzed the divalent cation specificity of poliovirus RNA-dependent RNA
polymerase, 3D pol. The following preference was observed: Mn 2+> Co 2+> Ni 2+> Fe 2+> …
polymerase, 3D pol. The following preference was observed: Mn 2+> Co 2+> Ni 2+> Fe 2+> …
The catalytic mechanism, metal dependence, substrate specificity, and biodiversity of ribonuclease H
J Pang, Q Guo, Z Lu - Frontiers in Microbiology, 2022 - frontiersin.org
Ribonucleoside monophosphates are inevitably misincorporated into the DNA genome
inside cells, and they need to be excised to avoid chromosome instability. Ribonucleases H …
inside cells, and they need to be excised to avoid chromosome instability. Ribonucleases H …
Inhibition of the Ribonuclease H and DNA Polymerase Activities of HIV-1 Reverse Transcriptase by N-(4-tert-Butylbenzoyl)-2-hydroxy-1-naphthaldehyde Hydrazone
G Borkow, RS Fletcher, J Barnard, D Arion… - Biochemistry, 1997 - ACS Publications
HIV-1 reverse transcriptase (RT) is multifunctional, with RNA-dependent DNA polymerase
(RDDP), DNA-dependent DNA polymerase (DDDP), and ribonuclease H (RNase H) …
(RDDP), DNA-dependent DNA polymerase (DDDP), and ribonuclease H (RNase H) …