Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside

X Bao, Y Liang, H Chang, T Cai, B Feng… - … and Targeted Therapy, 2024 - nature.com
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in
lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its …

Preparing for the next viral threat with broad-spectrum antivirals

M Karim, CW Lo, S Einav - The Journal of Clinical …, 2023 - Am Soc Clin Investig
There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …

Potential use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition and prevention method in viral infection

K Muzammil, MH Hooshiar, S Varmazyar… - Microbial Cell …, 2024 - Springer
Cellular lipid membranes serve as the primary barrier preventing viral infection of the host
cell and provide viruses with a critical initial point of contact. Occasionally, viruses can utilize …

[HTML][HTML] The bidirectional interaction of COVID-19 infections and lipoproteins

KR Feingold - Best Practice & Research Clinical Endocrinology & …, 2023 - Elsevier
COVID-19 infections decrease total cholesterol, LDL-C, HDL-C, and apolipoprotein AI, A-II,
and B levels while triglyceride levels may be increased or inappropriately normal for the …

Plasma Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) as a possible biomarker for severe COVID-19

P Mester, P Amend, S Schmid, M Müller, C Buechler… - Viruses, 2023 - mdpi.com
Proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces low density lipoprotein (LDL)
uptake, leading to increased plasma levels of LDL. In addition, PCSK9 has been implicated …

Emerging clinical role of proprotein convertase subtilisin/kexin type 9 inhibition–Part two: Current and emerging concepts in the clinical use of PCSK9 inhibition

AM Cao Zhang, E Ziogos, T Harb… - European Journal of …, 2024 - Wiley Online Library
Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have emerged
as a novel class of drugs with cardioprotective effects through their lipid‐lowering effects …

PCSK9, a promising novel target for age-related cardiovascular dysfunction

C Matyas, E Trojnar, S Zhao, M Arif… - Basic to Translational …, 2023 - jacc.org
Cardiovascular diseases (CVDs) are the leading cause of death among elderly people.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important regulator of …

Adjunctive therapy with lipid-lowering agents in COVID-19: a systematic review and meta-analysis of randomized controlled trials

A Khalaji, AH Behnoush, S Alilou, M Rezaee… - Lipids in Health and …, 2023 - Springer
Background Many commonly used drugs were evaluated as repurposed treatment options
since the emergence of the COVID-19 pandemic. The benefit of lipid-lowering agents has …

The multifaceted role of PCSK9 in cancer pathogenesis, tumor immunity, and immunotherapy

CY Hsu, MN Abdulrahim, MA Mustafa, TM Omar… - Medical Oncology, 2024 - Springer
Proprotein convertase subtilisin/kexin type 9 (PCSK9), a well-known regulator of cholesterol
metabolism and cardiovascular diseases, has recently garnered attention for its emerging …

Contrasting effects of intracellular and extracellular human PCSK9 on inflammation, lipid alteration and cell death

A Ghalali, F Alhamdan, S Upadhyay, K Ganguly… - Communications …, 2024 - nature.com
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is one of the major regulators of low-
density lipoprotein receptor (LDLR). Information on role and regulation of PCSK9 in lung is …