Over the past decade, new methods and procedures have been developed to generate
genetically engineered mouse models of human disease. This At a Glance article highlights …

The disease outbreak caused by Middle East respiratory syndrome coronavirus (MERS-
CoV) is still ongoing in the Middle East. Over 1700 people have been infected since it was …

The bone marrow microenvironment has a key role in regulating haematopoiesis, but its
molecular complexity and response to stress are incompletely understood. Here we map the …

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by
episodically exuberant heterotopic ossification (HO), whereby skeletal muscle is abnormally …

We have ablated the cellular RNA degradation machinery in differentiated B cells and
pluripotent embryonic stem cells (ESCs) by conditional mutagenesis of core (Exosc3) and …

Primary congenital glaucoma (PCG) is a devastating eye disease and an important cause of
childhood blindness worldwide. In PCG, defects in the anterior chamber aqueous humor …

The vast majority of the mammalian genome has the potential to express noncoding RNA
(ncRNA). The 11-subunit RNA exosome complex is the main source of cellular 3′–5 …

Glaucoma is a leading cause of blindness, afflicting more than 60 million people worldwide.
Increased intraocular pressure (IOP) due to impaired aqueous humor drainage is a major …

Genetic engineering is the use of molecular biology technology to modify DNA sequence (s)
in genomes, using a variety of approaches. For example, homologous recombination can be …

The advent of human-induced pluripotent stem cell (hiPSC) technology has provided a
unique opportunity to establish cellular models of disease from individual patients, and to …