Abstract Exportin 1 (XPO1), also known as chromosome region maintenance protein 1,
plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of …

Nuclear factor kappa B (NF-κB) signaling is implicated in all major human chronic diseases,
with its role in transcription of hundreds of gene well established in the literature. This has …

Background Selinexor combined with dexamethasone has shown activity in patients with
heavily pre-treated multiple myeloma. In a phase 1b/2 study, the combination of oral …

Background Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) is an aggressive
cancer with a median overall survival of less than 6 months. We aimed to assess the …

Selinexor is a first-in-class inhibitor of the nuclear exportin XPO1 that was recently approved
by the US Food and Drug Administration for the treatment of multiple myeloma and diffuse …

Obesity is a global pandemic that has been associated with the development of breast,
endometrial, large intestine, renal, esophageal, and pancreatic cancer. Obesity is also …

Abstract Exportin-1 (XPO1/CRM1) plays a central role in the nuclear-to-cytoplasmic transport
of hundreds of proteins and contributes to other cellular processes, such as centrosome …

塞利尼索是全球首个强效, 口服的核输出蛋白抑制剂, 具备独特的作用机制且影响多条信号通路,
能协同增强其他药物的抗肿瘤活性. 国内外多项临床研究证实以塞利尼索为基础的联合方案治疗 …

Purpose Selinexor is a novel XPO1 inhibitor which inhibits the export of tumor suppressor
proteins and oncoprotein mRNAs, leading to cell-cycle arrest and apoptosis in cancer cells …

Many patients worldwide receive platelet components (PCs) through the transfusion of
diverse types of blood components. PC transfusions are essential for the treatment of central …