Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Enhancers are genomic sequences that play a key role in regulating tissue-specific gene
expression levels. An increasing number of diseases are linked to impaired enhancer …

The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2,
BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional …

Sustained expression of programmed cell death receptor-1 (PD-1) is correlated with the
exhaustion of T cells, and blockade of the PD-1 pathway is an effective immunotherapeutic …

Chronic inflammation and tissue fibrosis are common responses that worsen organ function,
yet the molecular mechanisms governing their cross-talk are poorly understood. In diseased …

Glioma is a primary aggressive brain tumor with high recurrence rate. The poor efficiency of
chemotherapeutic drugs crossing the blood‒brain barrier (BBB) is well-known as one of the …

Epigenetic factor Brd4 has emerged as a key regulator of cancer cell proliferation. Targeted
inhibition of Brd4 suppresses growth and induces apoptosis of various cancer cells. In …

Epigenetics play a crucial role in gene regulation and cellular processes. Most importantly,
its dysregulation can contribute to the development of tumors. Epigenetic modifications, such …

Subunits of the chromatin remodeler SWI/SNF are the most frequently disrupted genes in
cancer. However, how post-translational modifications (PTM) of SWI/SNF subunits elicit …