Highlights•Host immune responses play both protective and pathogenic roles in IAV and
CoV infections.•Synergy of adaptive and innate immunity is required for efficient control of …

Background Cellular compositions of solid tumor microenvironments are heterogeneous,
varying across patients and tumor types. High-resolution profiling of the tumor …

The risk of emerging pandemic influenza A viruses (IAVs) that approach the devastating
1918 strain motivates finding strain-specific host–pathogen mechanisms. During infection …

The influenza virus is considered as a kind of significant zoonotic infectious disease
identified to date, with severe infections in humans characterized by excessive inflammation …

Host cells produce variety of antiviral factors that create an antiviral state and target various
stages of influenza A virus (IAV) life cycle to inhibit infection. However, IAV has evolved …

The initiation of an immune response is dependent on the activation and maturation of
dendritic cells after sensing pathogen associated molecular patterns by pattern recognition …

Motivation Gene set enrichment analyses (GSEAs) are widely used in genomic research to
identify underlying biological mechanisms (defined by the gene sets), such as Gene …

Pathway analysis is widely used to gain mechanistic insights from high-throughput omics
data. However, most existing methods do not consider signal integration represented by …

Avian influenza virus (AIV) can cross species barriers to infect humans and other mammals.
However, these species-cross transmissions are most often dead-end infections due to host …

Influenza A virus (IAV) is well-known to exploit host factors to its advantage. Here, we report
that IAV exploits host cortactin, an actin filament-stabilising protein for infection in epithelial …