Many members of the heat shock protein family act in unison to refold or degrade misfolded
proteins. Some heat shock proteins also directly interfere with apoptosis. These homeostatic …

Transcriptome study in neurodegenerative disease has advanced considerably in the past 5
years. Increasing scientific rigour and improved analytical tools have led to more …

Parkinson's disease affects 5 million people worldwide, but the molecular mechanisms
underlying its pathogenesis are still unclear. Here, we report a genome-wide meta-analysis …

Objective The PARK8 gene responsible for late‐onset autosomal dominant Parkinson's
disease encodes a large novel protein of unknown biological function termed leucine‐rich …

Multiple genetic and environmental factors play a role in the development and progression
of Parkinson's disease (PD). The main neuropathological hallmark of PD is the degeneration …

Parkinson's disease (PD) progresses relentlessly and affects five million people worldwide.
Laboratory tests for PD are critically needed for developing treatments designed to slow or …

Parkinson's disease is caused by a progressive loss of the midbrain dopamine (DA) neurons
in the substantia nigra pars compacta. Although the main cause of Parkinson's disease …

miRNAs were recently implicated in the pathogenesis of numerous diseases, including
neurological disorders such as Parkinson's disease (PD). miRNAs are abundant in the …

Subjects with incidental Lewy body disease (iLBD) may represent the premotor stage of
Parkinson's disease (PD). To elucidate molecular mechanisms underlying neuronal …

While selective neuronal death has been an influential theme in Huntington's disease (HD),
there is now a preponderance of evidence that significant neuronal dysfunction precedes …