A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer's disease agents: A review

S Manzoor, N Hoda - European journal of medicinal chemistry, 2020 - Elsevier
Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the
oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine …

Biocatalytic approaches to the synthesis of enantiomerically pure chiral amines

D Ghislieri, NJ Turner - Topics in Catalysis, 2014 - Springer
Enantiomerically pure chiral amines are valuable building blocks for the synthesis of
pharmaceutical drugs and agrochemicals. Indeed it is estimated that currently 40% of …

Assessment of enzyme inhibition: a review with examples from the development of monoamine oxidase and cholinesterase inhibitory drugs

RR Ramsay, KF Tipton - Molecules, 2017 - mdpi.com
The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …

A retrosynthesis approach for biocatalysis in organic synthesis

ROMA de Souza, LSM Miranda… - … –A European Journal, 2017 - Wiley Online Library
For the planning of an organic synthesis route, the disconnection approach guided by
retrosynthetic analysis of possible intermediates and the chemical reactions involved, back …

Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis

HU Cho, S Kim, J Sim, S Yang, H An, MH Nam… - … & Molecular Medicine, 2021 - nature.com
Monoamine oxidase (MAO) is believed to mediate the degradation of monoamine
neurotransmitters, including dopamine, in the brain. Between the two types of MAO, MAO-B …

Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: focus on modulation of CNS monoamine neurotransmitter release

JPM Finberg - Pharmacology & therapeutics, 2014 - Elsevier
Inhibitors of monoamine oxidase (MAO) were initially used in medicine following the
discovery of their antidepressant action. Subsequently their ability to potentiate the effects of …

Histone lysine methylation and demethylation pathways in cancer

RA Varier, HTM Timmers - Biochimica et Biophysica Acta (BBA)-Reviews …, 2011 - Elsevier
The genetic changes leading to the development of human cancer are accompanied by
alterations in the structure and modification status of chromatin, which represent powerful …

Current approaches to the treatment of Parkinson's Disease

JM Ellis, MJ Fell - Bioorganic & medicinal chemistry letters, 2017 - Elsevier
Parkinson's Disease (PD) is the second most common neurodegenerative disorder. Clinical
approaches to manage PD include symptomatic therapies, serving to compensate for the …

Black pepper and health claims: a comprehensive treatise

MS Butt, I Pasha, MT Sultan… - Critical reviews in …, 2013 - Taylor & Francis
For millennia, spices have been an integral part of human diets and commerce. Recently,
the widespread recognition of diet-health linkages bolsters their dietary importance. The …

Structures and mechanism of the monoamine oxidase family

H Gaweska, PF Fitzpatrick - 2011 - degruyter.com
Members of the monoamine oxidase family of flavoproteins catalyze the oxidation of primary
and secondary amines, polyamines, amino acids, and methylated lysine side chains in …