Aggregation-induced emission (AIE), life and health

H Wang, Q Li, P Alam, H Bai, V Bhalla, MR Bryce… - ACS …, 2023 - ACS Publications
Light has profoundly impacted modern medicine and healthcare, with numerous
luminescent agents and imaging techniques currently being used to assess health and treat …

Enhancing the stability of antimicrobial peptides: From design strategies to biomedical applications

S Xu, P Tan, Q Tang, T Wang, Y Ding, H Fu… - Chemical Engineering …, 2023 - Elsevier
Antimicrobial peptides (AMPs) offer unique advantages due to their membrane-active
antimicrobial mechanisms, which reduce the likelihood of resistance development …

Application of biomarker-derived fluorescent probes for the detection of Alzheimer's disease

H Ding, Z Li, K Luo, Q Gong, X Tian - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of beta-amyloid (Aβ) protein and neurofibrillary tangles in the brain, resulting …

[HTML][HTML] Aggregation-induced emission: An illuminator in the brain

Y Duo, Y Yang, T Xu, R Zhou, R Wang, G Luo… - Coordination Chemistry …, 2023 - Elsevier
The brain is the central control hub of the whole body. Hence, the consequences of brain
diseases can be lethal. Despite the progress in fundamental and clinical research, several …

Advances in targeted tracking and detection of soluble amyloid-β aggregates as a biomarker of Alzheimer's disease

H Gao, J Chen, Y Huang, R Zhao - Talanta, 2024 - Elsevier
Misfolding and aggregation of amyloid-β (Aβ) peptides are key hallmarks of Alzheimer's
disease (AD). With accumulating evidence suggesting that different Aβ species have varied …

Ganglioside GM1 produces stable, short, and cytotoxic Aβ 40 protofibrils

M Kumar, MI Ivanova, A Ramamoorthy - Chemical Communications, 2023 - pubs.rsc.org
Monosialoganglioside GM1-bound amyloid β-peptides have been found in patients' brains
exhibiting early pathological changes of Alzheimer's disease. Herein, we report the ability of …

Biosensing strategies for amyloid‐like protein aggregates

Y Zhou, S Yan, W Dong, C Wu, Z Zhao, R Wang… - …, 2024 - Wiley Online Library
Protein aggregate species play a pivotal role in the pathology of various degenerative
diseases. Their dynamic changes are closely correlated with disease progression, making …

Multi-target amyloid probing and inhibition using basic orange fluorescence

Y Tang, D Zhang, X Gong, J Zheng - Sensors & Diagnostics, 2023 - pubs.rsc.org
Misfolding and aggregation of amyloid peptides are critical pathological events in numerous
protein misfolding diseases (PMDs), such as Alzheimer's disease (AD), type II diabetes …

Nanostructured organic photosensitizer aggregates in disease phototheranostics

M Zheng, Q Yang, C Lu, X Wu, W Yan, D Liu - Drug Discovery Today, 2023 - Elsevier
Highlights•Focusing on disease phototheranostic applications of nanostructured organic
photosensitizer aggregates (NOPSAs).•Highlighting diverse NOPSAs including polymer …

Engineering Core/Ligands Interfacial Anchors of Nanoparticles for Efficiently Inhibiting Both Aβ and Amylin Fibrillization

Y Deng, G Gao, L Yu, Z Zhang, B Zhang, H Li, X Zhang… - Small, 2024 - Wiley Online Library
Accurate construction of artificial nano‐chaperones' structure is crucial for precise regulation
of protein conformational transformation, facilitating effective treatment of proteopathy …