Progress and Challenges in the Field of Snakebite Envenoming Therapeutics

JM Gutiérrez, N R. Casewell… - Annual Review of …, 2024 - annualreviews.org
Snakebite envenoming kills and maims hundreds of thousands of people every year,
especially in the rural settings of tropical regions. Envenomings are still treated with animal …

[HTML][HTML] Towards better antivenoms: navigating the road to new types of snakebite envenoming therapies

S Thumtecho, NJ Burlet, A Ljungars… - Journal of Venomous …, 2023 - SciELO Brasil
Snakebite envenoming is a significant global health challenge, and for over a century,
traditional plasma-derived antivenoms from hyperimmunized animals have been the primary …

[HTML][HTML] Discovery of a human monoclonal antibody that cross-neutralizes venom phospholipase A2s from three different snake genera

CV Sørensen, JR Almeida, MF Bohn… - Toxicon, 2023 - Elsevier
Despite the considerable global impact of snakebite envenoming, available treatments
remain suboptimal. Here, we report the discovery of a broadly-neutralizing human …

In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model

M Benard-Valle, Y Wouters, A Ljungars… - Nature …, 2024 - nature.com
Oligoclonal mixtures of broadly-neutralizing antibodies can neutralize complex compositions
of similar and dissimilar antigens, making them versatile tools for the treatment of eg …

Toxic Peptides from the Mexican Scorpion Centruroides villegasi: Chemical Structure and Evaluation of Recognition by Human Single-Chain Antibodies

L Riaño-Umbarila, T Olamendi-Portugal… - Toxins, 2024 - mdpi.com
Alternative recombinant sources of antivenoms have been successfully generated. The
application of such strategies requires the characterization of the venoms for the …

Discovery of broadly‐neutralizing antibodies against brown recluse spider and Gadim scorpion sphingomyelinases using consensus toxins as antigens

E Rivera‐de‐Torre, S Lampadariou… - Protein …, 2024 - Wiley Online Library
Broadly‐neutralizing monoclonal antibodies are becoming increasingly important tools for
treating infectious diseases and animal envenomings. However, designing and developing …

Fit‐for‐purpose heterodivalent single‐domain antibody for gastrointestinal targeting of toxin B from Clostridium difficile

ER Rodriguez Rodriguez, RT Nordvang… - Protein …, 2024 - Wiley Online Library
Abstract Single‐domain antibodies (sdAbs), such as VHHs, are increasingly being
developed for gastrointestinal (GI) applications against pathogens to strengthen gut health …

[HTML][HTML] V-ToCs (Venom Toxin Clustering): A tool for the investigation of sequence and structure similarities in snake venom toxins

K Kalogeropoulos, V Rosca, C O'Brien… - Toxicon, 2024 - Elsevier
Recently, there has been a major push toward the development of next-generation
treatments against snakebite envenoming. However, unlike current antivenoms that rely on …

[PDF][PDF] Fit-for-purpose heterodivalent single-domain antibody for gastrointestinal targeting of toxin B from

ERR Rodriguez, RT Nordvang, M Petersson… - 2024 - drive.google.com
Abstract Single-domain antibodies (sdAbs), such as VHHs, are increasingly being
developed for gastrointestinal (GI) applications against pathogens to strengthen gut health …

Design of consensus toxins and their use for the discovery of broadly neutralizing antibodies

AD Jensen - 2023 - orbit.dtu.dk
Snakebite envenoming remains a significant global health challenge, impacting millions of
people annually, particularly in regions with limited access to medical care. The primary …