Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

Mammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-
specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory …

During ribosome biogenesis, ribosomal RNAs acquire various chemical modifications that
ensure the fidelity of translation, and dysregulation of the modification processes can cause …

The function of RNA is subtly modulated by post-transcriptional modifications. Here, we
report an important crosstalk in the covalent modification of two classes of RNAs. We …

Regulation of messenger RNA translation is central to eukaryotic gene expression control.
Regulatory inputs are specified by the mRNA untranslated regions (UTRs) and often target …

Assembly factors (AFs) prevent premature translation initiation on small (40S) ribosomal
subunit assembly intermediates by blocking ligand binding. However, it is unclear how AFs …

We introduce a rational approach for associating genes with plant traits by combined use of
a genome-scale functional network and targeted reverse genetic screening. We present a …

To what extent can variation in phenotypic traits such as disease risk be accurately predicted
in individuals? In this Review, I highlight recent studies in model organisms that are relevant …

It has recently become clear that ribosomes are much more heterogeneous than previously
thought, with diversity arising from rRNA sequence and modifications, ribosomal protein …

In the final steps of yeast ribosome synthesis, immature translation-incompetent pre-40S
particles that contain 20S pre-rRNA are converted to the mature translation-competent …