Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …

Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of
thousands of individual neurons, identified genetically or by their connectivity, across …

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …

Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …

Neuropsychiatric phenotypes have long been known to be influenced by heritable risk
factors, directly confirmed by the past decade of genetic studies that have revealed specific …

The brain is composed of diverse neuronal and non-neuronal cell types with complex
regional connectivity patterns that create the anatomical infrastructure underlying cognition …

We report the generation of a multimodal cell census and atlas of the mammalian primary
motor cortex (MOp or M1) as the initial product of the BRAIN Initiative Cell Census Network …

Rodent studies have demonstrated that synaptic dynamics from excitatory to inhibitory
neuron types are often dependent on the target cell type. However, these target cell-specific …

To study how the brain drives cognition and behavior we need to understand its cellular
composition. Advances in single-cell transcriptomics have revolutionized our ability to …

In the neocortex, subcerebral axonal projections originate largely from layer 5 (L5)
extratelencephalic-projecting (ET) neurons. The highly distinctive morpho-electric properties …