COVID‐19 and toll‐like receptor 4 (TLR4): SARS‐CoV‐2 may bind and activate TLR4 to increase ACE2 expression, facilitating entry and causing hyperinflammation
MM Aboudounya, RJ Heads - Mediators of inflammation, 2021 - Wiley Online Library
Causes of mortality from COVID‐19 include respiratory failure, heart failure, and
sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that …
sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that …
Non-viral COVID-19 vaccine delivery systems
The novel corona virus termed severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has spread throughout the globe at a formidable speed, causing tens of millions of …
CoV-2) has spread throughout the globe at a formidable speed, causing tens of millions of …
Exploring the out of sight antigens of SARS-CoV-2 to design a candidate multi-epitope vaccine by utilizing immunoinformatics approaches
SARS-CoV-2 causes a severe respiratory disease called COVID-19. Currently, global health
is facing its devastating outbreak. However, there is no vaccine available against this virus …
is facing its devastating outbreak. However, there is no vaccine available against this virus …
Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus
AO Fadaka, NRS Sibuyi, DR Martin, M Goboza… - Scientific reports, 2021 - nature.com
Dengue poses a global health threat, which will persist without therapeutic intervention.
Immunity induced by exposure to one serotype does not confer long-term protection against …
Immunity induced by exposure to one serotype does not confer long-term protection against …
Immunoinformatics-guided designing of epitope-based subunit vaccine from Pilus assembly protein of Acinetobacter baumannii bacteria
Acinetobacter baumannii, a prominent pathogen responsible for chronic infections in the
blood, urinary tract, and lungs, has a high mortality due to its virulence and limited …
blood, urinary tract, and lungs, has a high mortality due to its virulence and limited …
Designing of a multi-epitope vaccine against the structural proteins of marburg virus exploiting the immunoinformatics approach
Marburg virus disease (MVD) caused by the Marburg virus (MARV) generally appears with
flu-like symptoms and leads to severe hemorrhagic fever. It spreads via direct contact with …
flu-like symptoms and leads to severe hemorrhagic fever. It spreads via direct contact with …
In silico design and immunoinformatics analysis of a universal multi-epitope vaccine against monkeypox virus
S Sanami, S Nazarian, S Ahmad, E Raeisi… - Plos one, 2023 - journals.plos.org
Monkeypox virus (MPXV) outbreaks have been reported in various countries worldwide;
however, there is no specific vaccine against MPXV. In this study, therefore, we employed …
however, there is no specific vaccine against MPXV. In this study, therefore, we employed …
Designing a multi-epitope vaccine candidate to combat MERS-CoV by employing an immunoinformatics approach
Currently, no approved vaccine is available against the Middle East respiratory syndrome
coronavirus (MERS-CoV), which causes severe respiratory disease. The spike glycoprotein …
coronavirus (MERS-CoV), which causes severe respiratory disease. The spike glycoprotein …
Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approaches
Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
coronavirus 2 (SARS-COV-2) is a significant threat to global health security. Till date, no …
coronavirus 2 (SARS-COV-2) is a significant threat to global health security. Till date, no …
[HTML][HTML] Multi-epitope chimeric vaccine design against emerging Monkeypox virus via reverse vaccinology techniques- a bioinformatics and immunoinformatics …
S Aiman, Y Alhamhoom, F Ali, N Rahman… - Frontiers in …, 2022 - frontiersin.org
The emerging monkeypox virus (MPXV) is a zoonotic orthopoxvirus that causes infections in
humans similar to smallpox. Since May 2022, cases of monkeypox (MPX) have been …
humans similar to smallpox. Since May 2022, cases of monkeypox (MPX) have been …