Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide: IUPHAR review 1

AJ Harmar, J Fahrenkrug, I Gozes… - British journal of …, 2012 - Wiley Online Library
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase‐activating polypeptide
(PACAP) are members of a superfamily of structurally related peptide hormones that …

Neuropeptides—an overview

T Hökfelt, C Broberger, ZQD Xu, V Sergeyev, R Ubink… - …, 2000 - Elsevier
The present article provides a brief overview of various aspects on neuropeptides,
emphasizing their multitude and their wide distribution in both the peripheral and central …

Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide

T Ishihara, R Shigemoto, K Mori, K Takahashi… - Neuron, 1992 - cell.com
Vasoactive intestinal polypeptide (VIP), a 28 amino acid peptide hormone, plays many
physiological roles in the peripheral and central nerve systems. A functional cDNA clone of …

Biophysical modeling with variational autoencoders for bimodal, single-cell RNA sequencing data

M Carilli, G Gorin, Y Choi, T Chari, L Pachter - Nature Methods, 2024 - nature.com
Here we present biVI, which combines the variational autoencoder framework of scVI with
biophysical models describing the transcription and splicing kinetics of RNA molecules. We …

AgeAnno: a knowledgebase of single-cell annotation of aging in human

K Huang, H Gong, J Guan, L Zhang, C Hu… - Nucleic Acids …, 2023 - academic.oup.com
Aging is a complex process that accompanied by molecular and cellular alterations. The
identification of tissue-/cell type-specific biomarkers of aging and elucidation of the detailed …

Molecular cloning and expression of a cDNA encoding the secretin receptor.

T Ishihara, S Nakamura, Y Kaziro, T Takahashi… - The EMBO …, 1991 - embopress.org
Secretin is a 27 amino acid peptide which stimulates the secretion of bicarbonate, enzymes
and potassium ion from the pancreas. A complementary DNA encoding the rat secretin …

Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin‐releasing hormone system: combined tracing and light and electron …

EM Van Der Beek, TL Horvath… - Journal of …, 1997 - Wiley Online Library
The timing and occurrence of the preovulatory luteinizing hormone (LH) surge in the female
rodent are critically dependent on the integrity of the suprachiasmatic nucleus (SCN) …

POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease

B Andersen, MG Rosenfeld - Endocrine reviews, 2001 - academic.oup.com
POU domain factors are transcriptional regulators characterized by a highly conserved DNA-
binding domain referred to as the POU domain. The structure of the POU domain has been …

Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling

R Cao, B Robinson, H Xu, C Gkogkas, A Khoutorsky… - Neuron, 2013 - cell.com
Protein synthesis is critical for circadian clock function, but little is known of how translational
regulation controls the master pacemaker in mammals, the suprachiasmatic nucleus (SCN) …

The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases

C Rodríguez-Rodríguez, M Telpoukhovskaia… - Coordination Chemistry …, 2012 - Elsevier
Metal-ion homeostasis in the brain is critical for many physiological functions, particularly in
the central nervous system where metals are essential in complex signaling pathways. Most …