miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis

CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

microRNAs biogenesis, functions and role in tumor angiogenesis

T Annese, R Tamma, M De Giorgis, D Ribatti - Frontiers in oncology, 2020 - frontiersin.org
microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They
target more than one mRNAs, thus influencing multiple molecular pathways, but also …

Regulation of the MIR155 host gene in physiological and pathological processes

TS Elton, H Selemon, SM Elton, NL Parinandi - Gene, 2013 - Elsevier
MicroRNAs (miRNAs), a family of small nonprotein-coding RNAs, play a critical role in
posttranscriptional gene regulation by acting as adaptors for the miRNA-induced silencing …

MicroRNAs as potential biomarkers in cancer: opportunities and challenges

H Lan, H Lu, X Wang, H Jin - BioMed research international, 2015 - Wiley Online Library
MicroRNAs (miRNAs) are a group of small noncoding RNAs (ncRNAs) that
posttranscriptionally regulate gene expression by targeting their corresponding messenger …

Selective release of microRNA species from normal and malignant mammary epithelial cells

L Pigati, SCS Yaddanapudi, R Iyengar, DJ Kim… - PloS one, 2010 - journals.plos.org
MicroRNAs (miRNAs) in body fluids are candidate diagnostics for a variety of conditions and
diseases, including breast cancer. One premise for using extracellular miRNAs to diagnose …

MicroRNAs: potential biomarkers for cancer diagnosis, prognosis and targets for therapy

WCS Cho - The international journal of biochemistry & cell biology, 2010 - Elsevier
MicroRNAs have a revolutionary impact on cancer research over recent years. They emerge
as important players in tumorigenesis, leading to a paradigm shift in oncology. The …

Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors

T Niinuma, H Suzuki, M Nojima, K Nosho, H Yamamoto… - Cancer research, 2012 - AACR
Large intergenic noncoding RNAs (lincRNA) have been less studied than miRNAs in
cancer, although both offer considerable theranostic potential. In this study, we identified …

The oncogenic role of miR-155 in breast cancer

S Mattiske, RJ Suetani, PM Neilsen, DF Callen - … epidemiology, biomarkers & …, 2012 - AACR
Abstract miR-155 is an oncogenic miRNA with well described roles in leukemia. However,
additional roles of miR-155 in breast cancer progression have recently been described. A …

Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas

ABY Hui, M Lenarduzzi, T Krushel, L Waldron… - Clinical cancer …, 2010 - AACR
Purpose: The objective of this study is to investigate the significance of microRNAs (miRNA)
in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) …

Fecal MicroRNAs as novel biomarkers for colon cancer screening

A Link, F Balaguer, Y Shen, T Nagasaka… - … , biomarkers & prevention, 2010 - AACR
Introduction: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths,
but currently available noninvasive screening programs have achieved only a modest …